100239-22-3

Upstream product

• 5405-41-4 ethyl 3-hydroxybutyrate 
• 100239-15-4 (E)-4-methoxy-N-((E)-2-methyl-3-phenylallylidene)aniline 
• 123003-88-3 3-Acetyl-1-(4-methoxy-phenyl)-4-((E)-1-methyl-2-phenyl-vinyl)-azetidin-2-one 
• 130194-62-6 1-(4-Methoxy-phenyl)-4-((E)-1-methyl-2-phenyl-vinyl)-azetidine-2,3-dione 
• 121766-42-5 (3S,4R)-3-Hydroxy-1-(4-methoxy-phenyl)-4-((E)-1-methyl-2-phenyl-vinyl)-azetidin-2-one 
• 121766-44-7 1-(4-Methoxy-phenyl)-4-((E)-1-methyl-2-phenyl-vinyl)-3-[1-nitro-eth-(Z)-ylidene]-azetidin-2-one 
• 121766-45-8 (3S,4R)-1-(4-Methoxy-phenyl)-4-((E)-1-methyl-2-phenyl-vinyl)-3-(1-nitro-ethyl)-azetidin-2-one 
• 122673-11-4 1-(4-methoxyphenyl)-4-(α-methylstyryl)azetidin-2-one 
• 75-07-0 acetaldehyde 

Downstream Products

• 123003-88-3 trans-3-acetyl-4-(α-methylstyryl)-1-(4-methoxyphenyl)azetidin-2-one 
• 122598-60-1 trans-3-(1-acetoxyethyl)-1-(4-methoxyphenyl)-4-(α-methylstyryl)azetidin-2-one 
• 123003-89-4 trans-3-(1-acetoxyethyl)-4-acetyl-1-(4-methoxyphenyl)azetidin-2-one 
• 123003-90-7 trans-4-acetoxy-3-(1-acetoxyethyl)-1-(4-methoxyphenyl)azetidin-2-one 

Relevant academic research and scientific papers

The α-Bromoester-Imine Condensation promoted by Zinc-Trimethylchlorosilane: A Stereospecific Short Formal Synthesis of (+/-)-Carbapenem Antibiotics and Realated Compounds

Ethyl bromoacetate reacts with imines in the presence of zinc activated by trimethylchlorosilane to give high yields of 3-unsubstituted β-lactams.

The Reformatsky Type Reaction of Gilman and Speeter in the Preparation of Valuable β-Lactams in Carbapenem Synthesis: Scope and Synthetic Utility

The preparation of apppropriately substituted 3-alkyl β-lactams from the Reformatsky type reaction of Gilman and Speeter is described.Treatment of Schiff bases derived from α-methylcinnamaldehyde and amines with ethyl α-bromobutyrate or ethyl α-bromoisova

SYNTHETIC UTILITY OF AZETIDINE-2,3-DIONES: A NEW APPROACH TO 3-HYDROXYETHYL-β-LACTAMS AND α-AMINOACID DERIVATIVES

Baeyer-Villiger oxidation of azetidine-2,3-diones provides a new route to α-aminoacid-N-carboxyanhydrides.Conversion of azetidine-2,3-diones into 3-acetyl-β-lactams is also described.

3-(1'-hydroxyethyl)-2-azetidinones from 3-hydroxybutyrates and N-arylaldimines

Dianion imine addition, cyclisation reaction between ethyl-3-hydroxybutyrate and the aldimines generates β-lactams with the hydroxyethyl side chain of thienamycin and related β-lactam antibiotics in place. The effects of the N-arylaldimine and the reactio