100251-91-0

Basic information

• Product Name: 4-Amino Propofol Hydrochloride
• Synonyms: 4-Amino Propofol Hydrochloride;4-AMino-2,6-bis(1-Methylethyl)phenol Hydrochloride;4-AMino-2,6-diisopropylphenol Hydrochloride;4-AMino-2,6-diisopropyl-phenol Hydrochloride
• CAS NO: 100251-91-0
• Molecular Formula: C₁₂H₁₉NO*ClH
• Molecular Weight: 229.7463
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 100251-91-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: Methanol
• CAS DataBase Reference: 4-Amino Propofol Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino Propofol Hydrochloride(100251-91-0)
• EPA Substance Registry System: 4-Amino Propofol Hydrochloride(100251-91-0)

Safety Data

• Hazardous Substances Data: 100251-91-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 1988-15-4 2,6-diisopropyl-4-aminophenol 
• 2078-54-8 2,6-diisopropylphenol 
• 1576-14-3 2,6-Diisopropyl-4-nitrophenol 

Downstream Products

• 15206-39-0 2,6-diisopropyl-4-hydroxyiminocyclohexa-2,5-dien-1-one 
• 1988-14-3 3,5-Diisopropylparacetamol 
• 1988-10-9 2,6-di(2-propyl)hydroquinone 
• 1988-11-0 2,6-diisopropyl-1,4-benzoquinone 
• 75531-68-9 N-(4-Hydroxy-3,5-diisopropyl-phenyl)-methanesulfonamide 
• 205443-82-9 acetic acid 4-acetylamino-2,6-diisopropyl-phenyl ester 

Relevant articles and documents

Isotopic effect study of propofol deuteration on the metabolism, activity, and toxicity of the anesthetic

The use of isotopic substitution to delay the oxidative metabolism of the anesthetic propofol 1 was studied. The aromatic hydrogens of propofol 1 were replaced by deuterium to produce the mono- and trideuterated derivatives 4 and 5. In vitro metabolic stu

Propofol analogues. Synthesis, relationships between structure and affinity at GABA(A) receptor in rat brain, and differential electrophysiological profile at recombinant human GABA(A) receptors

A number of propofol (2,6-diisopropylphenol) congeners and derivatives were synthesized and their in a vitro capability to affect GABA(A) receptors determined by the inhibition of the specific [35S]-tert- butylbicyclophosphorothionate ([35S]TBPS) binding to rat whole brain membranes. Introduction of halogen (Cl, Br, and I) and benzoyl substituents in the para position of the phenyl group resulted in ligands with higher potency at inhibiting [35S]TBPS binding. A quantitative structure - affinity relationship (QSAR) study demonstrated that affinity is enhanced by increases in lipophilicity of the ligand whereas affinity is adversely affected by increases in size of the substituent para to the phenolic hydroxyl group. Consistent with the displacement of [35S]TBPS and with the activation of GABA(A) receptors, we demonstrate that ligands displaying high affinity (i.e., 2-4, and 8) are able to increase GABA-stimulated chloride currents in oocytes expressing human GABA(A) receptors and to directly activate chloride currents in an electrophysiological assay. Among them, compound 4 showed a rather peculiar profile in the electrophysiological examination with cloned α1β2γ2 GABA(A) receptors. Indeed, compared to propofol, it displayed a much greater efficacy at potentiating GABA-elicited chloride currents, but a much lower efficacy at producing a direct activation of the chloride channel in the absence of GABA. This behavior may give to compound 4 pharmacological properties that are more similar to anxiolytic and anticonvulsant drugs than to those of general anesthetics.