100272-18-2

Basic information

• Product Name: (4-chlorophenyl)(4,5-diphenyl-1H-pyrazol-3-yl)methanone
• Synonyms: (4-chlorophenyl)(4,5-diphenyl-1H-pyrazol-3-yl)methanone
• CAS NO: 100272-18-2
• Molecular Weight: 358.827
• Mol File: 100272-18-2.mol

Chemical Properties

• CAS DataBase Reference: (4-chlorophenyl)(4,5-diphenyl-1H-pyrazol-3-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chlorophenyl)(4,5-diphenyl-1H-pyrazol-3-yl)methanone(100272-18-2)
• EPA Substance Registry System: (4-chlorophenyl)(4,5-diphenyl-1H-pyrazol-3-yl)methanone(100272-18-2)

Safety Data

• Hazardous Substances Data: 100272-18-2(Hazardous Substances Data)

Upstream product

• 25856-06-8 2,3-dibromo-1-(4-chloro-phenyl)-3-phenyl-propan-1-one 
• 956-02-5 4'-chlorochalcone 
• 100-52-7 benzaldehyde 
• 4996-21-8 1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone 

Relevant articles and documents

One-pot three-component approach to the synthesis of polyfunctional pyrazoles

A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.

Convenient access to polyfunctional pyrazoles via a highly efficient and regioselective multicomponent reaction

A multicomponent reaction has been developed for the synthesis of polyfunctional pyrazole derivatives from readily available arylglyoxal monohydrates, tosylhydrazine, and aldehydes or ketones. This synthetic method has significant advantages in broad substrate scope, excellent regioselectivity, and simple operation.