1003-52-7

Usage

Uses

Used in Pharmaceutical Industry:
4-METHYL-1,3-OXAZOLE-5-CARBONITRILE is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activity and unique chemical structure, contributing to the development of new drugs with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 4-METHYL-1,3-OXAZOLE-5-CARBONITRILE serves as an essential building block in the creation of agrochemicals, leveraging its versatile reactivity to produce compounds with applications in pest control and crop protection.
Used in Organic Synthesis:
4-METHYL-1,3-OXAZOLE-5-CARBONITRILE is utilized as a versatile building block in organic synthesis, enabling the construction of a wide range of organic compounds for various applications beyond pharmaceuticals and agrochemicals, such as in materials science and specialty chemicals.

InChI:InChI=1/C5H4N2O/c1-4-5(2-6)8-3-7-4/h3H,1H3

Upstream product

• 4866-00-6 4-methyl oxazole-5-carboxamide 
• 20485-39-6 ethyl 4-methyloxazole-5-carboxylate 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 

Downstream Products

• 4866-00-6 4-methyl oxazole-5-carboxamide 
• 106166-54-5 4-methyl-5-(4-phenyl-thiazol-2-yl)-oxazole 

Relevant academic research and scientific papers

A PROCESS FOR PREPARATION OF OXAZOLE COMPOUNDS

The present invention provides a new process for producing an oxazole compound of formula (I), which can avoid toxic and corrosive reagent, and salts by-products and has high efficiency,formula (I). Wherein R is H, or lower alkyl or aryl optionally substituted by one or more substituents.

A PROCESS FOR PRODUCING OXAZOLE COMPOUNDS

The present invention provides a new process for producing an oxazole compound of formula (I), which can avoid toxic reagents and reduce salts by-products with high efficiency, wherein R1 is H, or lower alkyl or aryl optionally substituted by one or more substituents; and E is C≡N, or C(=O)R' wherein R' is H, lower alkyl, aryl or lower alkoxyl.

A PROCESS FOR PREPARATION OF SUBSTITUTED ENAMINE COMPOUNDS

The present invention provides a substituted enamine compound of formula (I), and a process for producing oxazole compounds from the compound of formula (I). According to the processes of the present invention, it can produce substituted enamine compounds with high yield and selectivity while avoiding toxic or unsafe reagents for producing oxazole compounds. wherein R is H, lower alkyl or aryl, optionally substituted by one or more substituents.

Novel acyloxy enamine compound

The present invention provides a novel acyloxy enamine compound which can be used for the production of oxazole compounds. The invention also provides a method for preparing the acyloxy enamine compound. Compared with the prior art, the method is easier to operate in one pot and provides higher yield. Furthermore, the method of is carried out under mild conditions (at room temperature) and avoidsany salt, thus being environmentally friendly.

AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R 5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Process for the manufacture of 5-cyano-4-lower alkyl-oxazoles

A process for the manufacture of a 5-cyano-4-lower alkyl-oxazole by the dehydration of a 5-carbamoyl-4-lower alkyl-oxazole is disclosed. The reaction is carried out by dehydrating the oxazole with silicon tetrachloride in the presence of an amine in an aprotic organic solvent. 5-Carbamoyl-4-methyl-oxazole may be dehydrated by the process in accordance with the invention to obtain 5-cyano-4-methyl-oxazole, which is a valuable intermediate in the synthesis of pyridoxine.

Process for the manufacture of 5-cyano-4-lower alkyl-oxazoles

A process for the manufacture of 5-cyano-4-lower alkyl-oxazoles is described in which a 5-carbamoyl-4-lower alkyl-oxazole is dehydrated in an organic solvent under mild conditions with cyanuric chloride and an N,N-disubstituted-formamide.

Process for manufacturing 5-cyano-4-lower alkyloxazoles

The invention is concerned with a process for the manufacture of 5-cyano-4-lower alkyl-oxazoles by dehydrating a 5-carbamoyl-4-lower alkyl-oxazole in the gas phase in the presence of a heterogeneous catalyst based on silicon dioxide and in the presence of