1003022-51-2Relevant academic research and scientific papers
Donor-substituted nitrocyclopropanes: Immediate ring-enlargement to cyclic nitronates
Schmidt, Christian D.,Kaschel, Johannes,Schneider, Tobias F.,Kratzert, Daniel,Stalke, Dietmar,Werz, Daniel B.
, p. 6098 - 6101 (2013)
The reaction of donor-substituted alkenes with α-diazo-α-nitro ethyl acetate under Rh catalysis was investigated; respective nitrocyclopropanes with a geminal ester functionality were generated in situ. Strong electron donors immediately led to ring-enlargement. In all cases, the nitro group was inserted forming cyclic nitronates whereas the ester moiety was not incorporated into the ring system. DFT studies revealed that the formation of cyclic nitronates is kinetically as well as thermodynamically favored over the formation of cyclic ketene acetals.
Ring-opening 1,3-dichlorination of donor-acceptor cyclopropanes by iodobenzene dichloride
Garve, Lennart K.B.,Barkawitz, Philip,Jones, Peter G.,Werz, Daniel B.
, p. 5804 - 5807 (2014)
Donor-acceptor cyclopropanes are reacted with iodobenzene dichloride to afford ring-opened products bearing chlorine atoms in the 1- and 3-positions, adjacent to the donor and acceptor groups. A variety of different donors (e.g., alkyl, aryl, N, and O) and acceptor moieties (e.g., ketones, diesters, and dinitriles) are used.
N-ACYLIMINO HETEROCYCLIC COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS
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Page/Page column 181; 182, (2015/12/08)
The present invention relates to N-acylimino compound of formula (I). The invention also relates to the use of the N-acylimino heterocyclic compounds of formula (I), their stereoisomers, their tautomers and their salts, for combating invertebrate pests. Furthermore the invention relates also to methods of combating invertebrate pests, which comprises applying such compounds.
Hypervalent iodine(iii)-mediated cyclopropa(e)nation of alkenes/alkynes under mild conditions
Lin, Shaoxia,Li, Mengru,Dong, Zhiyong,Liang, Fushun,Zhang, Jingping
, p. 1341 - 1350 (2014/03/21)
Hypervalent iodine(iii)-mediated dioxygenation and diamination of alkenes have been previously developed. In this study, the potential application of hypervalent iodine(iii) reagent was successfully extended to the dialkylation and cyclopropa(e)nation of
CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A
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Page/Page column 62, (2014/06/24)
(I) The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
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Paragraph 0107, (2014/06/24)
The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
An Expedient and Practical Method for the Synthesis of A Diverse Series of Cyclopropane α-Amino Acids and Amines
Wurz, Ryan P.,Charette, Andre B.
, p. 1262 - 1269 (2007/10/03)
A practical synthesis for the preparation of a diverse series of cyclopropane α-amino acids is described. Nitrocyclopropane carboxylates can be readily prepared through treatment of α-nitroesters and iodobenzene diacetate or α-nitro-α-diazoesters with a R
Synthesis of α-nitro-α-diazocarbonyl derivatives and their applications in the cyclopropanation of alkenes and in O - H insertion reactions
Charette, Andre B.,Wurz, Ryan P.,Ollevier, Thierry
, p. 4468 - 4484 (2007/10/03)
A facile and highly efficient method for the preparation of α-nitroα-diazocarbonyl derivatives by a diazotransfer reaction involving (trifluoromethyl) sulfonyl azide has been developed. These substrates undergo a rhodium-catalyzed cyclopropanation reaction with a variety of alkenes. A systematic study of the reaction indicated that the diastereoselectivity of the cyclopropanation could be effectively controlled through the modification of the steric bulk of the diazo reagent. A novel O - H insertion reaction of the metal - carbene complex derived from the α-nitro-α-diazocarbonyl reagent afforded the corresponding novel α-nitro-α-alkoxy carbonyl derivatives.
