1003221-10-0

Upstream product

• 6952-59-6 3-cyanobromobenzene 
• 173406-70-7 3-bromo-N'-hydroxybenzenecarboximidamide 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 16796-52-4 3-bromobenzene-1-carboximidamide hydrochloride 
• 108-88-3 toluene 
• 3741-66-0 Ethyl benzoyl carbonate 
• 1137-94-6 1-(2-phenyl-2-oxoethyl)pyridinium iodide 

Downstream Products

• 1572343-36-2 3-(3-(9H-[3,9'-bicarbazol]-9-yl)phenyl)-5-phenyl-1,2,4-oxadiazole 

Relevant academic research and scientific papers

Direct synthesis of 3,5-diaryl-1,2,4-oxadiazoles using 1-(2-oxo-2-arylethyl)pyridin-1-iums with benzamidines

An efficient domino protocol for the synthesis of 1,2,4-oxadiazole derivatives from readily available 1-(2-oxo-2-arylethyl)pyridin-1-iums and amidine hydrochlorides was developed. In this practical approach, N-acyl amidine precursors were formed firstly via a simple nucleophilic substitution, without the purification of N-acylamidine intermediates, and the following intramolecularly dehydrative cyclization gave 1,2,4-oxadiazole derivatives in the presence of I2/K2CO3/DMSO, which exhibited excellent functional group tolerance and proceeded under simple experimental conditions.

A facile approach to synthesize 3,5-disubstituted-1,2,4-oxadiazoles via copper-catalyzed-cascade annulation of amidines and methylarenes

Various 3,5-disubstituted-1,2,4-oxadiazoles are smoothly formed via copper-catalyzed cascade annulation of amidines and methylarenes. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 1,2,4-oxadiazoles from easily available starting materials, with inexpensive copper catalysts and green oxidants. It has the advantages of atom- and step-economy, good functional group tolerance, as well as operational simplicity.

METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Asymmetric design of bipolar host materials with novel 1,2,4-oxadiazole unit in blue phosphorescent device

The intrinsic asymmetry of 1,2,4-oxadiazole was utilized to synthesize three isomers, DCzmOXD-1, DCzmOXD-2, and mCzmOXD, and high triplet energies over 2.80 eV made them good candidates for host materials in blue OLEDs. The best efficiencies of 23.0 cd A