100366-89-0Relevant academic research and scientific papers
Synthesis of cyclic imides from nitriles and diols using hydrogen transfer as a substrate-activating strategy
Kim, Jaewoon,Hong, Soon Hyeok
, p. 4404 - 4407 (2014)
An atom-economical and versatile method for the synthesis of cyclic imides from nitriles and diols was developed. The method utilizes a Ru-catalyzed transfer-hydrogenation reaction in which the substrates, diols, and nitriles are simultaneously activated into lactones and amines in a redox-neutral manner to afford the corresponding cyclic imides with evolution of H2 gas as the sole byproduct. This operationally simple and catalytic synthetic method provides a sustainable and easily accessible route to cyclic imides.
Dramatic Reversal of Diastereoselectivity in an N-Acyliminium Ion Cyclization Leading to Hexahydropyrroloisoquinolines. A Case of Competing Steric Interactions
Maryanoff, Bruce E.,McComsey, David F.,Almond, Harold R.,Mutter, Martin S.,Bemis, Guy W.,et al.
, p. 1341 - 1346 (2007/10/02)
The N-acyliminium ion cyclization 1 -> 2 + 3 (eq 1) with various aliphatic substituents (R = ethyl, cyclohexyl, and tert-butyl) was carried out, as an extension of our work in ref 2.The following 2:3 ratios were obtained: 39:61, 12:88, and 15:85, respecti
