34577-88-3Relevant academic research and scientific papers
Cobalt-based nanoparticles prepared from MOF-carbon templates as efficient hydrogenation catalysts
Murugesan, Kathiravan,Senthamarai, Thirusangumurugan,Sohail, Manzar,Alshammari, Ahmad S.,Pohl, Marga-Martina,Beller, Matthias,Jagadeesh, Rajenahally V.
, p. 8553 - 8560 (2018/11/30)
The development of efficient and selective nanostructured catalysts for industrially relevant hydrogenation reactions continues to be an actual goal of chemical research. In particular, the hydrogenation of nitriles and nitroarenes is of importance for the production of primary amines, which constitute essential feedstocks and key intermediates for advanced chemicals, life science molecules and materials. Herein, we report the preparation of graphene shell encapsulated Co3O4- and Co-nanoparticles supported on carbon by the template synthesis of cobalt-terephthalic acid MOF on carbon and subsequent pyrolysis. The resulting nanoparticles create stable and reusable catalysts for selective hydrogenation of functionalized and structurally diverse aromatic, heterocyclic and aliphatic nitriles, and as well as nitro compounds to primary amines (>65 examples). The synthetic and practical utility of this novel non-noble metal-based hydrogenation protocol is demonstrated by upscaling several reactions to multigram-scale and recycling of the catalyst.
Chemoselective hydrogenation of nitriles to primary amines catalyzed by water-soluble transition metal catalysts
Nait Ajjou, Abdelaziz,Robichaud, André
, (2018/08/07)
The water-soluble rhodium complex generated in situ from [Rh (COD)Cl]2 in aqueous ammonia has been revealed as a highly efficient catalyst for the hydrogenation of aromatic nitriles, to primary amines with excellent yields. The catalyst is also highly selective towards primary amines in the case of sterically hindered aliphatic nitriles. The catalytic system can also be recycled and re-used with no significant loss of activity.
Dramatic Reversal of Diastereoselectivity in an N-Acyliminium Ion Cyclization Leading to Hexahydropyrroloisoquinolines. A Case of Competing Steric Interactions
Maryanoff, Bruce E.,McComsey, David F.,Almond, Harold R.,Mutter, Martin S.,Bemis, Guy W.,et al.
, p. 1341 - 1346 (2007/10/02)
The N-acyliminium ion cyclization 1 -> 2 + 3 (eq 1) with various aliphatic substituents (R = ethyl, cyclohexyl, and tert-butyl) was carried out, as an extension of our work in ref 2.The following 2:3 ratios were obtained: 39:61, 12:88, and 15:85, respecti
