100367-36-0

Usage

Uses

Used in Scientific Research:
Phenol, 3-amino-2-bromo-, is used as an intermediate chemical in laboratory synthesis for various applications. Its unique structure with a bromine atom and an amino group attached to a phenol ring makes it a valuable compound for the development of new chemical entities and the study of chemical reactions.
Used in Chemical Synthesis:
In the field of chemical synthesis, Phenol, 3-amino-2-bromo-, serves as a key intermediate for the production of various organic compounds. Its reactivity and functional groups allow for a wide range of chemical transformations, making it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Development:
Phenol, 3-amino-2-bromo-, is used as a starting material or intermediate in the development of pharmaceutical compounds. Its unique structure and reactivity enable the creation of new drug candidates with potential therapeutic applications. Researchers can exploit its functional groups to design and synthesize novel molecules with desired biological activities.
Used in Agrochemical Production:
In the agrochemical industry, Phenol, 3-amino-2-bromo-, is utilized as a precursor in the synthesis of various agrochemicals, such as pesticides and herbicides. Its chemical properties and reactivity make it suitable for the development of new compounds with improved efficacy and selectivity in controlling pests and weeds.
Used in Specialty Chemicals:
Phenol, 3-amino-2-bromo-, is also employed in the production of specialty chemicals, which are used in various industries such as coatings, adhesives, and plastics. Its unique structure and reactivity contribute to the development of innovative products with enhanced performance characteristics.

Upstream product

• 603-85-0 2-Amino-3-nitrophenol 
• 56619-93-3 N-(3-methoxyphenyl)pivalamide 
• 168335-63-5 Hexanoic acid 2-bromo-3-(2,2-dimethyl-propionylamino)-phenyl ester 
• 101935-40-4 2-bromo-3-hydroxy-1-nitrobenzene 
• 168335-61-3 N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide 

Downstream Products

• 169531-06-0 (S)-4-[(E)-3-(3-Amino-2-bromo-phenoxy)-propenyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 168335-72-6 (S)-4-[(Z)-3-(3-Amino-2-bromo-phenoxy)-propenyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 591-27-5 m-Hydroxyaniline 
• 863870-88-6 2-bromo-3-iodophenol 
• 1420012-89-0 C₁₇H₂₆BrNOSi 
• 1420012-69-6 C₁₆H₂₄BrNOSi 
• 168335-67-9 (S)-4-[4-((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-benzofuran-3-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 112970-46-4 2-bromo-3-hydroxy-N-tosylaniline 

Relevant academic research and scientific papers

Induction of Axial Chirality in 8-Arylquinolines through Halogenation Reactions Using Bifunctional Organocatalysts

The enantioselective syntheses of axially chiral heterobiaryls were accomplished through the aromatic electrophilic halogenation of 3-(quinolin-8-yl)phenols with bifunctional organocatalysts that control the molecular conformations during successive halogenations. Axially chiral quinoline derivatives, which have rarely been synthesized in an enantioselective catalytic manner, were afforded in moderate-to-good enantioselectivities through bromination, and an analogous protocol also enabled enantioselective iodination. In addition, this catalytic reaction, which allows enantioselective control through the use of mono-ortho-substituted substrates, allowed the asymmetric synthesis of 8-arylquinoline derivatives bearing two different halogen groups in high enantioselectivities.

QUINAZOLINE COMPOUNDS

The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Effect of alteration of the heterocyclic nucleus of ILV on its isoform selectivity for PKC. Palladium catalyzed route to benzofuran analogues of ILV

A palladium catalyzed route for the preparation of several benzofuran analogues of the PKC activator indolactam V (ILV) is described together with the ability of these compounds to activate the isoforms of PKC. The benzofuran analogues of ILV are shown to activate PKC with a slightly different pattern of isotype selectivity than ILV or 7-n-octyl-ILV. Moreover, in an examination of the effect of stereochemistry at the C-14 center of the teleocidins on PKC binding activity, a clear preference for R-stereochemistry at the C-14 center was found, thus providing additional verification of previously published structural correlations between the families of PKC activators.

Effect of alteration of the heterocyclic nucleus of ILV on its isoform selectivity for PKC. Palladium-catalyzed route to benzofuran analogues of ILV

The discovery of isoform-selective modulators of protein kinase C (PKC) appears worthwhile in further defining the roles of the individual PKC isoforms in cell type-specific processes. In comparison with the phorbol esters, little information is available

Palladium-Catalyzed Coupling of 2-Bromoanilines with Vinylstannanes. A Regiocontrolled Synthesis of Substituted Indoles

The palladium-catalyzed cross-coupling reaction of aryl halides and triflates with vinylstannane reagents has been used to produce a variety of substituted indoles.The mild reaction conditions and selectivity inherent in the coupling reaction have been utilized to produce regiochemically pure 4-, 5-, and 6-substituted indoles.