100391-40-0

Basic information

• Product Name: N-phenyl-L-aspartic acid dimethyl ester
• Synonyms: N-phenyl-L-aspartic acid dimethyl ester
• CAS NO: 100391-40-0
• Molecular Weight: 237.255
• Mol File: 100391-40-0.mol

Chemical Properties

• CAS DataBase Reference: N-phenyl-L-aspartic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-L-aspartic acid dimethyl ester(100391-40-0)
• EPA Substance Registry System: N-phenyl-L-aspartic acid dimethyl ester(100391-40-0)

Safety Data

• Hazardous Substances Data: 100391-40-0(Hazardous Substances Data)

Upstream product

• 4916-29-4 dimethyl 2-(phenyl-amino)-2-butendioate 
• 62-53-3 aniline 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 6384-18-5 L-Aspartic acid dimethyl ester 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 67-56-1 methanol 
• 54229-53-7 N-phenyl-L-aspartic acid 
• 58109-40-3 diphenyliodonium hexafluorophosphate 
• 591-50-4 iodobenzene 
• 1483-73-4 diphenyliodonium bromide 
• 17763-67-6 Phenyl triflate 

Downstream Products

• 2226-83-7 N-phenyl-DL-aspartic acid ; inactive anilinosuccinic acid 
• 36920-53-3 4-oxo-1,2,3,4-tetrahydroquinoline-2-carboxylic acid 
• 374790-76-8 (S)-2-(2-Methylaminomethyl-phenylamino)-succinic acid dimethyl ester 
• 54229-53-7 N-phenyl-L-aspartic acid 

Relevant articles and documents

Development of a Method for the N-Arylation of Amino Acid Esters with Aryl Triflates

A general method for the N-arylation of amino acid esters with aryl triflates is described. Both α- and β-amino acid esters, including methyl, tert-butyl, and benzyl esters, are viable substrates. Reaction optimization was carried out by design of experim

Reaction of arynes with amino acid esters

An efficient route to a variety of 2-phenylindolin-3-ones from amino acid methyl esters has been developed. The reaction of amino acid methyl esters with benzyne prepared from 2-(trimethylsilyl)phenyl triflate and CsF gave 2-phenylindolin-3-ones in moderate to good yields.

Use of diphenyliodonium bromide in the synthesis of some N-phenyl-amino acids

The N-phenyl methyl esters 4 of glycine, alanine, valine, leucine, isoleucine, phenylalanine, methionine, proline, serine, threonine, tyrosine, aspartic acid, and glutamic acid have been synthesized in good to excellent yields using diphenyliodonium bromide, AgNO3, and a catalytic amount of CuBr starting from the relevant amino acid ester. The chiral integrity of the amino acids 5 was maintained during these reactions, which were confirmed by the synthesis of dipeptide for each N-phenyl amino acid. The structures of the new compounds were confirmed by the analysis of their IR, 1H, and 13C NMR spectra in addition to CHN microanalysis or high-resolution mass spectrometry for the new N-phenyl amino acids 5 and the esters 4.

Synthesis of SB-214857 using copper catalysed amination of arylbromides with L-aspartic acid

An efficient synthesis of a 1,4-benzodiazepine was accomplished using copper catalysed amination of an arylbromide with the soluble bis-tetrabutylammonium salt of L-aspartic acid as a key step.

2-Carboxytetrahydroquinolines. Conformational and Stereochemical Requirements for Antagonism of the Glycine Site on the NMDA Receptor

2-Carboxy-1,2,3,4-tetrahydroquinoline derivatives, derived from kynurenic acid, have been synthesized and evaluated for in vitro antagonist activity at the glycine site on the NMDA receptor. 2,3-Dihydrokynurenic acids show reduced potency relative to the