1004-01-9

Basic information

• Product Name: 5-bromopyrimidine-2,4-diamine
• Synonyms: 5-bromopyrimidine-2,4-diamine
• CAS NO: 1004-01-9
• Molecular Formula: C₄H₅BrN₄
• Molecular Weight: 189.0133
• Mol File: 1004-01-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 422.5±48.0 °C(Predicted)
• Appearance: /
• Density: 1.956±0.06 g/cm3(Predicted)
• PKA: 5.25±0.10(Predicted)
• CAS DataBase Reference: 5-bromopyrimidine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromopyrimidine-2,4-diamine(1004-01-9)
• EPA Substance Registry System: 5-bromopyrimidine-2,4-diamine(1004-01-9)

Safety Data

• Hazardous Substances Data: 1004-01-9(Hazardous Substances Data)

Usage

General Description

5-Bromopyrimidine-2,4-diamine is a chemical compound that consists of a pyrimidine ring with a bromine atom at the 5th position and an amine group at the 2nd and 4th positions. It is used in the pharmaceutical industry as a building block for the synthesis of potential drug candidates. The presence of the bromine atom and the amine groups make it a versatile compound for various chemical reactions, leading to the formation of diverse molecules with potential biological activities. Its structural properties and reactivity make it a valuable intermediate in the production of various pharmaceuticals and agrochemicals. Overall, 5-bromopyrimidine-2,4-diamine is an important chemical with potential applications in drug discovery and development.

Upstream product

• 156-81-0 2,4-diaminopyrimidine 

Downstream Products

• 892498-86-1 5-amino-3H-thiazolo[4,5-d]pyrimidine-2-thione 
• 944401-61-0 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2,4-diamine 
• 865304-71-8 5-(2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine 
• 156-81-0 2,4-diaminopyrimidine 

Relevant articles and documents

Development of a robust and sustainable process for nucleoside formation

A practical and robust process for the synthesis of an Isatoribine pro-drug was demonstrated. The process relies on a streamlined glycosylation carried out in xylene and an effective regioselective enzymatic hydrolysis that can be run in a semicontinuous way. Analysis of the process mass intensity established the high impact from an environmental standpoint of our process improvement.

METHOD OF INHIBITING HAMARTOMA TUMOR CELLS

Dimorpholinopyrimidines are useful for inhibiting growth or proliferation of hamartoma tumor cells. Because the Dimorpholinopyrimidines inhibit the growth and proliferation of hamartoma tumor cells they are also useful in treating PTEN hamartoma tumor syndromes. The therapeutic and prophylactic treatments provided by this invention are practiced by administering to a patient in need thereof an amount of a compound of dimorpholinopyrimidine derivative that is effective to inhibit growth or proliferation of the hamartoma tumor cells.

PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE

Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, auutoimmune and cardiovascular diseases.