1004-01-9

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromopyrimidine-2,4-diamine is used as a building block for the synthesis of potential drug candidates due to its ability to participate in various chemical reactions, leading to the formation of diverse molecules with potential biological activities.
Used in Drug Discovery and Development:
5-bromopyrimidine-2,4-diamine is utilized as an important intermediate in drug discovery and development, owing to its structural properties and reactivity that contribute to the creation of molecules with potential therapeutic applications.
Used in Agrochemical Production:
5-Bromopyrimidine-2,4-diamine is also used in the production of various agrochemicals, where its chemical reactivity and structural features are leveraged to develop compounds with pesticidal or herbicidal properties.

Upstream product

• 156-81-0 2,4-diaminopyrimidine 

Downstream Products

• 156-81-0 2,4-diaminopyrimidine 
• 944401-61-0 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2,4-diamine 
• 865304-71-8 5-(2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine 
• 892498-86-1 5-amino-3H-thiazolo[4,5-d]pyrimidine-2-thione 

Relevant academic research and scientific papers

Development of a robust and sustainable process for nucleoside formation

A practical and robust process for the synthesis of an Isatoribine pro-drug was demonstrated. The process relies on a streamlined glycosylation carried out in xylene and an effective regioselective enzymatic hydrolysis that can be run in a semicontinuous way. Analysis of the process mass intensity established the high impact from an environmental standpoint of our process improvement.

Preparation method of amine compound

The invention relates to a preparation method of an amine compound, and belongs to the field of medicinal chemistry. According to the preparation method, 2-isopropyl-4-methoxyphenol is used as a starting material, and the amine compound can be obtained th

METHOD OF INHIBITING HAMARTOMA TUMOR CELLS

Dimorpholinopyrimidines are useful for inhibiting growth or proliferation of hamartoma tumor cells. Because the Dimorpholinopyrimidines inhibit the growth and proliferation of hamartoma tumor cells they are also useful in treating PTEN hamartoma tumor syndromes. The therapeutic and prophylactic treatments provided by this invention are practiced by administering to a patient in need thereof an amount of a compound of dimorpholinopyrimidine derivative that is effective to inhibit growth or proliferation of the hamartoma tumor cells.

Identification of NVP-BKM120 as a potent, selective, orally bioavailable class i PI3 kinase inhibitor for treating cancer

Phosphoinositide-3-kinases (PI3Ks) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. Herein we describe the structure guided optimization of a series of 2-morpholino, 4-substituted, 6-heterocyclic pyrimidines where the pharmacokinetic properties were improved by modulating the electronics of the 6-position heterocycle, and the overall druglike properties were fine-tuned further by modification of the 4-position substituent. The resulting 2,4-bismorpholino 6-heterocyclic pyrimidines are potent class I PI3K inhibitors showing mechanism modulation in PI3K dependent cell lines and in vivo efficacy in tumor xenograft models with PI3K pathway deregulation (A2780 ovarian and U87MG glioma). These efforts culminated in the discovery of 15 (NVP-BKM120), currently in Phase II clinical trials for the treatment of cancer.

PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE

Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, auutoimmune and cardiovascular diseases.

Novel process for the preparation of 5-amino-3H-thiazolo[4,5-d]pyrimidin-2-one

The present invention relates to a process for the preparation of the title compound, 5-amino-3H-thiazolo[4,5-d]pyrimidin-2-one, which is a useful intermediate in the preparation of certain thiazolo[4,5-d]pyrimidine nucleosides, which can have utility as immunomodulators.

PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS

Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof ; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.