1004-96-2Relevant articles and documents
Substituent effects in isoxazoles: Identification of 4-substituted isoxazoles as Michael acceptors
Lee, Connie K.Y.,Easton, Christopher J.,Gebara-Coghlan, Mariana,Radom, Leo,Scott, Anthony P.,Simpson, Gregory W.,Willis, Anthony C.
, p. 2031 - 2038 (2002)
Crystallographic and theoretical studies have been used to investigate substituent effects, which are manifest in electrochemical and yeast-catalysed reactions of 4- and 5-acyl-, alkoxycarbonyl-, cyano- and phenyl-substituted isoxazoles. The results show that isoxazoles substituted at the 4-position with π-electron-withdrawing substituents have enhanced C4-C5 bond polarity and are structurally similar to Michael acceptors. As a consequence there is elongation and weakening of their N-O bonds. By contrast, their 5-substituted regioisomers and isoxazoles substituted at C4 with conjugating, but not π-electron-withdrawing, substituents have diminished C4-C5 bond polarity. This results in the selective electrochemical and yeast-catalysed reduction of 4-substituted isoxazoles, as well as their hydrogenolytic ring cleavage and conjugate reduction with sodium borohydride.
HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS
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Paragraph 0671-0672; 0673, (2018/06/12)
Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
HETEROCYCLIC NUCLEAR HORMONE RECEPTOR MODULATORS
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Paragraph 0700, (2014/07/08)
The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
