100483-82-7

Upstream product

• 2538-76-3 1,1'-benzylidenedipiperidine 
• 123-54-6 acetylacetone 
• 4335-90-4 3-benzylidene acetylacetone 
• 31771-33-2 2-phenyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 
• 100-52-7 benzaldehyde 

Downstream Products

• 101587-85-3 1-(6-hydroxy-3,6-dimethyl-4-phenyl-4,5,6,7-tetrahydro-1⁽²⁾H-indazol-5-yl)-ethanone 
• 64-19-7 acetic acid 
• 5337-88-2 3-methyl-5-phenyl-2-cyclohexen-1-one 
• 180985-11-9 2-(7-Acetyl-4-cyano-6-hydroxy-1,6-dimethyl-8-phenyl-5,6,7,8-tetrahydro-isoquinolin-3-ylsulfanyl)-acetamide 
• 1309791-32-9 7-acetyl-6-hydroxy-1,6-dimethyl-8-phenyl-3-selenoxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile 
• 1367796-35-7 7-acetyl-2,4,6,7,8,9-hexahydro-8-hydroxy-5,8-dimethyl-2,6-diphenyl-1H-pyrazolo[3,4-c]isoquinolin-1-one 
• 1265901-99-2 7-acetyl-8-hydroxy-5,8-dimethyl-6-phenyl-6,7,8,9-tetrahydro[1,2,4]triazolo[3,4-b]quinazoline 

Relevant academic research and scientific papers

Nonsteroidal estrogen receptor isoform-selective biphenyls

Estrogen receptor (ER) has been a therapeutic target to treat ER-positive breast cancer, most notably by agents known as selective estrogen receptor modulators (SERMs). However, resistance and severe adverse effects of known drugs gave impetus to the sear

An efficient regioselective synthesis of functionalized biphenyls via sequential reactions of aromatic aldehydes and β-keto esters or ketones

Knoevenagel/Michael/Aldol reactions of aromatic aldehydes and β-keto esters/ketones in a sequential manner yielded intermediate cyclohexanones in good yields. The latter, on oxidative aromatization with iodine, afforded functionalized biphenyls with at le

Microwave assisted rapid and efficient synthesis of 2,1-benzoisoxazoles

A simple extremely fast and high yielding protocol has been developed for the synthesis of 2,1-benzisoxazoles under microwave irradiation.

A synthetic entry into fused pyran derivatives through carbon transfer reactions of 1,3-oxazinanes and oxazolidines with carbon nucleophiles

Acid catalysed condensations of various 2 substituted 1,3-oxazinanes 3 and 1,3-oxazolidines 4 with cyclic carbon nucleophiles viz. 5,5-dimethyl-1,3-cyclohexanedione and 1,3-cyclohexanedione furnish xanthene derivatives, whereas a Knoevenagel reaction proceeds with acyclic nucleophiles. In case of 4b and 4c, a unique synthesis of functionalised α-tetralones has emerged. Reactions of mixtures of cyclic and acyclic carbon nucleophiles with 3 provide some functionalised and partially reduced benzopyran derivatives.

THE MECHANISM OF THE HANTZSCH PYRIDINE SYNTHESIS: A STUDY BY 15N AND 13C NMR SPECTROSCOPY

The mechanism of the reactions of ammonia and benzaldehyde with three different beta-dicarbonyl compounds to form the corresponding dihydropyridines has been followed by NMR.In each case the pathway is shown to involve the reaction of benzaldehyde with one molecule of beta-dicarbonyl to give chalcone, and of the ammonia with a second molecule of beta-dicarbonyl to give an enamine.The rate determing stage is shown to be the Michael addition of the chalcone to the enamine.

Identification of Isomers by 2D-INADEQUATE NMR: Synthesis and Antibacterial Activity of 5-Acetyl-4-aryl-6-hydroxy-3,6-dimethyl-4,5,6,7-tetrahydro-2,1-benzisoxazoles

5-Acetyl-4-aryl-6-hydroxy-3,6-dimethyl-4,5,6,7-tetrahydro-2,1-benzisoxazoles (II) have been prepared by the cyclization of 2,4-diacetyl-4-aryl-5-hydroxy-5-methyl-cyclohexanones (I) with hydroxylamine hydrochloride.Heteronuclear correlated 2D NMR and 2D IN

Syntheses of Polysubstituted Cyclohexanones and Cyclohexanols

Reactions of aromatic aldehydes with alkyl aceto-acetates and acetylacetone have been studied.In the former case the reaction yields only one epimer (1, 2) and in the latter a mixture of epimers (4, 5) are obtained.Acid-catalysed selective dehydration of