100557-22-0

Usage

General Description

4-Amino-1-(phenylsulfonyl)-indole is a heterocyclic compound with the molecular formula C14H11N3O2S. It is an indole derivative with a phenylsulfonyl substituent at the 1-position and an amino group at the 4-position. This chemical has potential applications in medicinal chemistry and drug development due to its structural features and potential pharmacological properties. It is important for researchers to thoroughly study 4-Amino-1-(phenylsulfonyl)-indole in order to understand its biological activity, potential therapeutic uses, and potential side effects. Overall, 4-Amino-1-(phenylsulfonyl)-indole is a compound of interest in the field of medicinal chemistry and may have promising applications in drug discovery and development.

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 4769-97-5 4-nitro-1H-indoIe 
• 850655-62-8 4-nitro-1-(phenylsulfonyl)-1H-indole 
• 95969-08-7 1-benzenesulfonyl-5-chloro-4-oxo-4,5,6,7-tetrahydroindole 

Downstream Products

• 850655-63-9 N-(1-benzenesulfonyl-1H-indol-4-yl)-2-bromoacetamide 
• 1022158-71-9 6-(1-benzenesulfonyl-1H-indol-4-ylamino)-2-chloro-5-nitro-pyrimidine-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia

Mutants of the FLT3 receptor tyrosine kinase (RTK) with duplications in the juxtamembrane domain (FLT3-ITD) act as drivers of acute myeloid leukemia (AML). Potent tyrosine kinase inhibitors (TKi) of FLT3-ITD entered clinical trials and showed a promising,

SYNTHESIS, PHARMACOLOGY AND USE OF NEW AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) FLT3 INHIBITORS

The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the com

TETRAHYDROISOQUINOLINE DERIVATIVES

The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

ISOINDOLINE DERIVATIVES

The present invention relates to isoindoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

PROCESS FOR THE PREPARATION OF 2,4-DICHLORO-7H-PYRROLO[2,3H]QUINAZOLINE

The invention relates to a method of preparing 2,4-dichloro-7H-pyrrolo[2,3-h]quinazoline (II): from 1H-pyrrolo[2,3-h]quinazoline-2,4-dione.

HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS

Provided herein are Heteroaryl Compounds having the following structure: (I) wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

NOVEL TETRAYDROSPIRO{PIPERIDINE-2,7’ -PYRROLO[3,2-b]PYRIDINE DERIVATIVES AND NOVEL INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF 5-HT6 RECEPTOR -RELATED DISORDERS

The present invention relates to compounds of formula (I): Formula (I) wherein U, P, W1, W2, W3, v, Y, Z, Rm, and Rm’ are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.

A FACILE ONE STEP SYNTHESIS OF 4-AMINOINDOLES FROM 5-HALO-4-OXO-4,5,6,7-TETRAHYDROINDOLES

Reaction of 5-halo-4-oxo-4,5,6,7-tetrahydroindoles with amines initiates the amination of the carbonyl function and ensuing dehydrohalogenation leads to a successful formation of 4-aminoindoles.