1005646-26-3

Upstream product

• 100-52-7 benzaldehyde 
• 89-25-8 edaravone 
• 141-97-9 ethyl acetoacetate 
• 100-63-0 phenylhydrazine 
• 100-51-6 benzyl alcohol 

Relevant academic research and scientific papers

Synthesis, crystal structure, Hirshfeld surface, DFT and docking studies of 4-[(5?hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(phenyl)methyl]-5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

In the present work, 4-[(5?hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(phenyl)methyl]-5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (BPZ) was synthesized by one pot multicomponent reaction of ethylacetoacetate, phenylhydrazine and benzaldehyde in the pres

Palladium N-heterocyclic carbene catalyzed expected and unexpected C-C and C-N functionalization reactions of 1-aryl-3-methyl-1: H -pyrazol-5(4 H)-ones

A palladium N-heterocyclic carbene [Pd(NHC)Cl2] complex of vitamin B1 developed earlier in our laboratory was successfully employed as an efficient catalyst for the regioselective C-C and C-N functionalization reactions of 1-aryl-3-methyl-1H-pyrazol-5(4H)-ones 1a-b. The catalyst was attempted for the C-H arylation, acylation and alkoxylation of 1a-b using the respective coupling substrates such as aryl iodides 2a-c, benzylic alcohols 3a-d and methanol/ethanol 4. It was surprisingly noted that the acylation and alkoxylation reactions underwent a diverse pathway to yield some unexpected products rather than the targeted ones. In the case of the arylation reactions only the targeted products have been observed. This has made the protocol very interesting compared to the conventional coupling reactions.

An efficient one-pot synthesis of pyrazolone derivatives promoted by acidic ionic liquid

A new class of pyrazolone derivatives has been isolated in good to excellent yields from the 2 : 1 condensation reaction between 3-methyl-1-phenyl-5-pyrazolone and arylaldehydes in the presence of ionic liquid [HMIM]HSO4. The compounds were cha