1006592-90-0

Upstream product

• 88196-70-7 (R)-1-(3-methoxyphenyl)ethylamine 
• 120681-06-3 (E)-3-(2-chlorophenyl)acryloyl chloride 
• 1085449-72-4 N-[1-(3-methoxyphenyl)ethyl]-2-(toluene-4-sulfonyl)acetamide 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 1372628-56-2 3-((R)-1-((R)-1-phenylethylamino)ethyl)phenol 
• 1167414-89-2 (R)-1-(3-methoxyphenyl)ethanamine hydrochloride salt 
• 121-71-1 3-Hydroxyacetophenone 
• 518060-42-9 (R)-1-(3-hydroxyphenyl)ethylamine 
• 871728-33-5 (R)-[1-(3-methoxyphenyl)ethyl]carbamic acid tert-butyl ester 
• 266369-69-1 (R)-[1-(3-hydroxyphenyl)ethyl]carbamic acid tert-butyl ester 

Downstream Products

• 177172-48-4 (R)-3-(2-chlorophenyl)-N-(1-(3'-methoxyphenyl)ethyl)propanamide 
• 148717-49-1 tecalcet 

Relevant academic research and scientific papers

General strategy for large-scale synthesis of (+)-rivastigmine and (+)-NPS R-568

An economically viable strategy for the total synthesis of (+)-rivastigmine and (+)-NPS R-568 has been reported. The strategy involves regioselective hydrogenation of diastereomerically pure bis amine to realize the desired a-methyl chiral substituted benzyl amine. The route is economical, scalable, and versatile enough to be adapted to similar classes of compounds. Taylor & Francis Group, LLC.

N-isopropylsulfinylimines as useful intermediates in the synthesis of chiral amines: Expeditive asymmetric synthesis of the calcimimetic (+)-NPS R-568

(Chemical Equation Presented) An efficient and high-yielding approach for the asymmetric synthesis of calcimimetic (+)-NPS R-568 (1) has been developed. The key step of the synthesis is the highly diastereoselective addition of methyl Grignard to the (Ss

A practical and efficient synthesis of (E)-β-aryl-α,β-unsaturated amides

In this paper, we report a one-step convergent synthesis of (E)-β-monosubstituted α,β-unsaturated amides 3 from α-sulfonyl acetamide 1 and benzyl bromide derivatives 2.