1006875-90-6

Upstream product

• 1006875-89-3 1-(4-bromo-3-fluorophenyl)-2,2-dihydroxyethanone 
• 122-51-0 orthoformic acid triethyl ester 
• 153556-42-4 4-bromo-3-fluorobenzoic acid 
• 304445-49-6 1-(4-bromo-3-fluorophenyl)ethan-1-one 
• 343564-56-7 4-bromo-3-fluoro-N-methoxy-N-methyl-benzamide 
• 695188-21-7 4-bromo-3-fluorobenzoyl chloride 
• 1029714-83-7 2-(4-bromo-3-fluorophenyl)-2-oxoacetaldehyde 

Downstream Products

• 1006875-91-7 6-(4-bromo-3-fluorophenyl)-3-(methylthio)-1,2,4-triazine 
• 1029714-84-8 6-(4-bromo-3-fluorophenyl)-1,2,4-triazin-3-amine 
• 1029714-86-0 6-((2-(4-bromo-3-fluorophenyl)imidazo[1,2-b][1,2,4]triazin-7-yl)methyl)quinoline 
• 1029714-87-1 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile 
• 1332952-19-8 2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide 

Relevant academic research and scientific papers

IMIDAZO[1,2-B][1,2,4]TRIAZINES AS C-MET INHIBITORS

The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases including cancer.

SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-b][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME

The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.