695188-21-7

Basic information

• Product Name: 4-Bromo-3-fluorobenzoyl chloride
• Synonyms: 4-Bromo-3-fluorobenzoyl chloride
• CAS NO: 695188-21-7
• Molecular Formula: C₇H₃BrClFO
• Molecular Weight: 237.4535232
• Mol File: 695188-21-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 246.1°C at 760 mmHg
• Flash Point: 102.6°C
• Appearance: /
• Density: 1.742g/cm³
• Vapor Pressure: 0.0276mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 4-Bromo-3-fluorobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-fluorobenzoyl chloride(695188-21-7)
• EPA Substance Registry System: 4-Bromo-3-fluorobenzoyl chloride(695188-21-7)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 695188-21-7(Hazardous Substances Data)

Usage

Description

4-Bromo-3-fluorobenzoyl chloride is a synthetic, halogenated chemical compound that belongs to the class of organobromides and organochlorides. It contains bromine, fluorine, and a benzoyl group, which is a compound derived from benzoic acid where one of the hydrogen atoms is replaced by a chlorine atom. 4-Bromo-3-fluorobenzoyl chloride is primarily utilized in the field of chemistry for various organic synthesis processes. Its properties include specific boiling and melting points, and its chemical structure gives it significant reactivity. Proper handling and storage are essential as it can cause severe burns and eye damage.

Uses

Used in Chemical Synthesis:
4-Bromo-3-fluorobenzoyl chloride is used as a reagent in chemical synthesis for the preparation of various organic compounds. Its unique structure and reactivity make it a valuable component in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
4-Bromo-3-fluorobenzoyl chloride is used as an intermediate in the synthesis of pharmaceutical compounds. Its properties allow for the creation of new drug molecules with potential therapeutic applications.
Used in Material Science:
4-Bromo-3-fluorobenzoyl chloride is used as a building block in the development of new materials with specific properties, such as improved thermal stability or chemical resistance, which can be utilized in various industries.
Used in Research and Development:
4-Bromo-3-fluorobenzoyl chloride is used as a research compound in academic and industrial laboratories to study its chemical properties and potential applications in various fields, including chemistry, materials science, and pharmaceuticals.

InChI:InChI=1/C7H3BrClFO/c8-5-2-1-4(7(9)11)3-6(5)10/h1-3H

Upstream product

• 153556-42-4 4-bromo-3-fluorobenzoic acid 
• 136434-77-0 4-bromo-3-fluoroiodobenzene 

Downstream Products

• 1415758-93-8 (S)-tert-butyl 2-(4-(1-(4-(difluoromethoxy)phenyl)-1H-1,2,3-triazole-4-carboxamido)-3-fluorophenyl)morpholine-4-carboxylate 
• 1415757-58-2 (S)-tert-butyl 2-(4-(1-(3-(difluoromethoxy)phenyl)-1H-pyrazole-4-carboxamido)-3-fluorophenyl)morpholine-4-carboxylate 
• 1415756-24-9 2-methyl-5-phenyl-2H-pyrazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide 
• 1415756-03-4 6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide 
• 1415757-59-3 (S)-2-{4-[(4-Cyano-pyridine-2-carbonyl)-amino]-3-fluoro-phenyl}-morpholine-4-carboxylic acid tert-butyl ester 
• 1415756-80-7 (S)-4-Cyano-N-(2-fluoro-4-(morpholin-2-yl)phenyl)picolinamide hydrochloride 
• 1415757-44-6 (R)-2-{3-fluoro-4-[(2-methyl-5-phenyl-2H-pyrazole-3-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester 
• 1415757-41-3 (R)-2-{4-[3-(3-cyano-phenyl)-ureido]-3-fluoro-phenyl}-morpholine-4-carboxylic acid tert-butyl ester 
• 1415757-40-2 (R)-2-{3-fluoro-4-[(6-fluoro-1H-indazole-3-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester 
• 1415756-05-6 1-(3-cyano-phenyl)-3-((R)-2-fluoro-4-morpholin-2-yl-phenyl)-urea 
• 1400997-48-9 (-)-(S)-2-(4-amino-3-fluorophenyl)-morpholine-4-carboxylic acid tert-butyl ester 
• 1400997-47-8 (+)-(R)-2-(4-amino-3-fluorophenyl)-morpholine-4-carboxylic acid tert-butyl ester 
• 1400997-35-4 (RS)-2-(4-bromo-3-fluorophenyl)-oxirane 
• 1260857-14-4 2-chloro-1-(4-bromo-3-fluorophenyl)-ethanone 

Relevant articles and documents

ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR

Disclosed are compounds inhibiting the conversion of α–KG to D-2-HG, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition c

Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides

Current methods for functional group interconversion have, for the most part, relied on relatively strong driving forces which often require highly reactive reagents to generate irreversibly a desired product in high yield and selectivity. These approaches generally prevent the use of the same catalytic strategy to perform the reverse reaction. Here we describe a catalytic functional group metathesis approach to interconvert, under CO-free conditions, two synthetically important classes of electrophiles that are often employed in the preparation of pharmaceuticals and agrochemicals—aroyl chlorides (ArCOCl) and aryl iodides (ArI). Our reaction design relies on the implementation of a key reversible ligand C–P bond cleavage event, which enables a non-innocent, metathesis-active phosphine ligand to mediate a rapid aryl group transfer between the two different electrophiles. Beyond enabling a practical and safer approach to the interconversion of ArCOCl and ArI, this type of ligand non-innocence provides a blueprint for the development of a broad range of functional group metathesis reactions employing synthetically relevant aryl electrophiles.

BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY

A compound of formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of a histone deacetylase, and as such is useful in terepy, e.g. in the treatment of autoimmune disorders, mental disorders, neurodegenerative disorders, and hyperproliferative disorders.