1029714-87-1

Basic information

• Product Name: 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile
• Synonyms: 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile
• CAS NO: 1029714-87-1
• Molecular Weight: 380.384
• Mol File: 1029714-87-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile(1029714-87-1)
• EPA Substance Registry System: 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile(1029714-87-1)

Safety Data

• Hazardous Substances Data: 1029714-87-1(Hazardous Substances Data)

Upstream product

• 1197377-31-3 1-(2-chloro-1-hydroxy-3-(quinolin-6-yl)propyl)pyrrolidine-2,5-dione 
• 1029714-84-8 6-(4-bromo-3-fluorophenyl)-1,2,4-triazin-3-amine 
• 304445-49-6 1-(4-bromo-3-fluorophenyl)ethan-1-one 
• 695188-21-7 4-bromo-3-fluorobenzoyl chloride 
• 343564-56-7 4-bromo-3-fluoro-N-methoxy-N-methyl-benzamide 
• 153556-42-4 4-bromo-3-fluorobenzoic acid 
• 1006875-90-6 1-(4-bromo-3-fluorophenyl)-2,2-diethoxyethanone 
• 476660-18-1 3-(quinolin-6-yl)propanal 
• 5332-25-2 6-bromoquinoline 
• 1197377-47-1 4-(3-amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 
• 557-21-1 zinc(II) cyanide 
• 1029714-86-0 6-((2-(4-bromo-3-fluorophenyl)imidazo[1,2-b][1,2,4]triazin-7-yl)methyl)quinoline 
• 557-21-1 dicyanozinc 

Downstream Products

• 1029714-88-2 2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid 
• 1332952-19-8 2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide 
• 1029712-80-8 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide 
• 1029713-99-2 2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide 

Relevant articles and documents

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 2-FLUORO-N-METHYL-4-[7-QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-B][1,2,4]TRIAZIN-2YL]BENZAMIDE

The present invention relates to a novel chemical process for the synthesis of the compound 2- fluoro-N-methyl-4-[7-quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2yl]benzamide.

SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-b][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME

The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.