1007107-45-0

Upstream product

• 851542-50-2 (SiR)-1-tert-butyl-1,2,3,4-tetrahydro-1-silanaphthalene 
• 73853-36-8 2-<2-Hydroxy-2-(-p-methoxyphenyl)ethyl>pyridine 
• 1227475-37-7 bis(3,5-dimethylphenyl)(methyl)silane 
• 10420-97-0 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone 
• 109-06-8 α-picoline 
• 7465-86-3 4-methoxy-N,N-diethylbenzamide 

Relevant academic research and scientific papers

Highly efficient asymmetric bioreduction of 1-aryl-2-(azaaryl)ethanones. Chemoenzymatic synthesis of lanicemine

Different ketoreductases (KREDs) have been used to promote a highly selective reduction of several 1-aryl-2-(azaaryl)ethanones (azaaryl = pyridinyl, quinolin-2-yl), the corresponding secondary alcohols being obtained with very high yields and enantiomeric excesses (ee > 99%). The absolute configuration of each optically active alcohol has been assigned by means of modified Mosher and Kelly methods, two shielding effects being evaluated: (1) the Mosher phenyl ring effect on the azaaryl protons and (2) the one of the azaaryl ring on the Mosher methoxy group. In addition, the biologically active amine lanicemine has been synthesized from (R)-1-phenyl-2-(pyridin-2-yl)ethanol, thus proving the utility of the secondary alcohols here prepared.

Catalytic asymmetric Si-O coupling of simple achiral silanes and chiral donor-functionalized alcohols

"Chemical Equation Presented" Biomimetic and efficient: Mixed calcium manganese(III) oxides (see structure; Ca green, Mn red, O white) with elemental compositions and structures mimicking the active site of photosystem II were found to be highly active catalysts for the oxidation of water to molecular oxygen. As for PSII, the presence of Ca2+ greatly enhances the catalyst performance in comparison to the related manganeseonly system Mn2O3.

Chiral recognition with silicon-stereogenic silanes: Remarkable selectivity factors in the kinetic resolution of donor-functionalized alcohols

(Chemical Equation Presented) Slick silicon: A low-molecular-weight silane (C13H20Si, 204.38 g mol-1) with silicon-centered chirality is capable of discriminating enantiomeric rhodium-substrate complexes in dehydrogenative Si-O coupling reactions with outstanding selectivity factors (see scheme, s = selectivity factor).