10420-97-0

Basic information

• Product Name: 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone
• CAS NO: 10420-97-0
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.2585
• Mol File: 10420-97-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 390.6°C at 760 mmHg
• Flash Point: 190.1°C
• Density: 1.142g/cm³
• Vapor Pressure: 2.61E-06mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone(10420-97-0)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone(10420-97-0)

Safety Data

• Hazardous Substances Data: 10420-97-0(Hazardous Substances Data)

Usage

General Description

1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone is a chemical compound with the molecular formula C15H13NO2. It is also known by the trade name 4'-Methoxy-2-pyridylacetophenone and is commonly used as a reagent in organic synthesis. 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone is a yellow solid at room temperature and is soluble in organic solvents such as ethanol and acetone. It is commonly used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone is also used as an intermediate in the synthesis of other compounds and is known for its aromatic properties.

Upstream product

• 109-06-8 α-picoline 
• 874-90-8 4-methoxybenzonitrile 
• 74115-45-0 (Z)-1-(4-methoxy-phenyl)-2-[2]pyridyl-vinyl alcohol 
• 303162-29-0 (4-methoxyphenyl)(2-methylaziridin-1-yl)methanone 
• 109-72-8 n-butyllithium 
• 121-98-2 methyl 4-methoxybenzoate 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 7465-86-3 4-methoxy-N,N-diethylbenzamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 17881-80-0 (2-picolyl)trimethylsilane 

Downstream Products

• 1435893-00-7 2-(4-methoxyphenyl)-4H-quinolizin-4-one 
• 1007107-45-0 (R)-1-(4-methoxyphenyl)-2-( pyridin-2-yl)ethanol 
• 97422-43-0 [4-(4-methoxyphenyl)-5-(2-pyridyl)-1,3-thiazol-2-yl]amine 
• 881383-42-2 1-(4-methoxyphenyl)-2-[N-(3-methoxyphenyl)-N-methylamino]-2-(pyridin-2-yl)ethanone 
• 881383-41-1 1-(4-methoxyphenyl)-2-(N-ethyl-N-phenylamino)-2-(pyridin-2-yl)ethanone 
• 881383-40-0 1-(4-methoxyphenyl)-2-(N-methyl-N-phenylamino)-2-(pyridin-2-yl)ethanone 
• 881383-39-7 1-(4-methoxyphenyl)-2-(3-methoxyphenyl)amino-2-(pyridin-2-yl)ethanone 
• 881383-38-6 1-(4-methoxyphenyl)-2-phenylamino-2-(pyridin-2-yl)ethanone 

Relevant articles and documents

Tautomer-selective derivatives of enolate, ketone and enaminone by addition reaction of picolyl-type anions with nitriles

We describe an efficient for the synthesis of compounds of tautomeric β-pyridyl/quinolyl-enol, -ketone, -enaminone, which were finally characterized by standard methods like NMR, IR or SCXRD. The addition reaction of lithiated intermediates of picoline, 2-ethylpyridine and 2-methylquinoline, respectively, with nitriles followed by acid hydrolysis afforded the corresponding tautomeric compounds of enol, ketone and emaminone. Interestingly, treatment of 2-methylpyridine or 2-ethylpyridine with nitriles, respectively, yielded mostly β-pyridyl ketone and enol tautomers without enaminones, while 2-methylquinoline with nitriles gave β-quinolyl ketone and enaminone tautomers without enols. The reaction of 2-benzylpyridine with nitriles was not available under the same conditions.

Catalytic α-Arylation of Ketones with Heteroaromatic Esters

Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed α-arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of aromatic esters, the present work will allow for rapid access to valuable α-aryl carbonyl compounds.

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists

To investigate the potency of an adenosine A3 receptor (A 3AR) antagonist as an anti-asthmatic drug, a novel series of 4-phenyl-5-pyridyl-1,3-thiazole derivatives was synthesized and evaluated in human adenosine A1, A