10420-97-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone is used as a reagent for the synthesis of various pharmaceutical compounds due to its versatile chemical structure and solubility in organic solvents. Its ability to interact with other molecules makes it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone is used as a reagent in the synthesis of agrochemicals, contributing to the development of pesticides and other products that aid in crop protection and enhancement.
Used in Organic Synthesis:
As a reagent in organic synthesis, 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone is used for the production of a wide range of fine chemicals. Its aromatic properties and solubility in organic solvents make it a preferred choice for various chemical reactions and the creation of complex molecular structures.
Used as an Intermediate:
1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone is also used as an intermediate in the synthesis of other compounds, highlighting its importance in the chemical industry for creating a diverse array of products.

Upstream product

• 109-06-8 α-picoline 
• 874-90-8 4-methoxybenzonitrile 
• 303162-29-0 (4-methoxyphenyl)(2-methylaziridin-1-yl)methanone 
• 109-72-8 n-butyllithium 
• 121-98-2 methyl 4-methoxybenzoate 
• 7465-86-3 4-methoxy-N,N-diethylbenzamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 74115-45-0 (Z)-1-(4-methoxy-phenyl)-2-[2]pyridyl-vinyl alcohol 
• 17881-80-0 (2-picolyl)trimethylsilane 

Downstream Products

• 773013-64-2 2-bromo-1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone 
• 881383-43-3 1-(4-methoxyphenyl)-2-[N-(3-methoxyphenyl)-N-ethylamino]-2-(pyridin-2-yl)ethanone 
• 881383-44-4 3-(4-methoxyphenyl)-2-(pyridin-2-yl)-1H-indole 
• 881383-45-5 3-(4-methoxyphenyl)-1-methyl-2-(pyridin-2-yl)-1H-indole 
• 881383-46-6 1-ethyl-3-(4-methoxyphenyl)-2-(pyridin-2-yl)-1H-indole 
• 881383-47-7 6-methoxy-3-(4-methoxyphenyl)-1-methyl-2-(pyridin-2-yl)-1H-indole 
• 881383-48-8 1-ethyl-6-methoxy-3-(4-methoxyphenyl)-2-(pyridin-2-yl)-1H-indole 
• 881383-38-6 1-(4-methoxyphenyl)-2-phenylamino-2-(pyridin-2-yl)ethanone 
• 881383-39-7 1-(4-methoxyphenyl)-2-(3-methoxyphenyl)amino-2-(pyridin-2-yl)ethanone 
• 881383-40-0 1-(4-methoxyphenyl)-2-(N-methyl-N-phenylamino)-2-(pyridin-2-yl)ethanone 
• 881383-41-1 1-(4-methoxyphenyl)-2-(N-ethyl-N-phenylamino)-2-(pyridin-2-yl)ethanone 
• 881383-42-2 1-(4-methoxyphenyl)-2-[N-(3-methoxyphenyl)-N-methylamino]-2-(pyridin-2-yl)ethanone 
• 1435893-00-7 2-(4-methoxyphenyl)-4H-quinolizin-4-one 

Relevant academic research and scientific papers

Tautomer-selective derivatives of enolate, ketone and enaminone by addition reaction of picolyl-type anions with nitriles

We describe an efficient for the synthesis of compounds of tautomeric β-pyridyl/quinolyl-enol, -ketone, -enaminone, which were finally characterized by standard methods like NMR, IR or SCXRD. The addition reaction of lithiated intermediates of picoline, 2-ethylpyridine and 2-methylquinoline, respectively, with nitriles followed by acid hydrolysis afforded the corresponding tautomeric compounds of enol, ketone and emaminone. Interestingly, treatment of 2-methylpyridine or 2-ethylpyridine with nitriles, respectively, yielded mostly β-pyridyl ketone and enol tautomers without enaminones, while 2-methylquinoline with nitriles gave β-quinolyl ketone and enaminone tautomers without enols. The reaction of 2-benzylpyridine with nitriles was not available under the same conditions.

Highly efficient asymmetric bioreduction of 1-aryl-2-(azaaryl)ethanones. Chemoenzymatic synthesis of lanicemine

Different ketoreductases (KREDs) have been used to promote a highly selective reduction of several 1-aryl-2-(azaaryl)ethanones (azaaryl = pyridinyl, quinolin-2-yl), the corresponding secondary alcohols being obtained with very high yields and enantiomeric excesses (ee > 99%). The absolute configuration of each optically active alcohol has been assigned by means of modified Mosher and Kelly methods, two shielding effects being evaluated: (1) the Mosher phenyl ring effect on the azaaryl protons and (2) the one of the azaaryl ring on the Mosher methoxy group. In addition, the biologically active amine lanicemine has been synthesized from (R)-1-phenyl-2-(pyridin-2-yl)ethanol, thus proving the utility of the secondary alcohols here prepared.

Catalytic α-Arylation of Ketones with Heteroaromatic Esters

Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed α-arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of aromatic esters, the present work will allow for rapid access to valuable α-aryl carbonyl compounds.

Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation

4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner-Wadsworth-Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups.

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists

To investigate the potency of an adenosine A3 receptor (A 3AR) antagonist as an anti-asthmatic drug, a novel series of 4-phenyl-5-pyridyl-1,3-thiazole derivatives was synthesized and evaluated in human adenosine A1, A

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors

A novel series of 4-phenyl-5-pyridyl-1,3-thiazole analogues possessing potent in vitro inhibitory activity against p38 mitogen-activated protein kinase and the release of tumor necrosis factor-α (TNF-α) from human monocytic THP-1 cells stimulated by lipopolysaccharide has been identified. Subsequent structure-activity relationship (SAR) studies and optimization for absorption, distribution, metabolism, and elimination (ADME) profiles led to the identification of compounds 7g and 10b as orally active lead candidates that block the in vivo production of proinflammatory cytokine (TNF-α). In pharmacokinetic studies, compound 10b showed good oral administration in mice and demonstrated significant in vivo anti-inflammatory activity in an anti-collagen monoclonal antibody-induced arthritis mouse model (minimum effective dose (MED)=30 mg/kg). Further elucidation of this class of compounds may provide novel anti-inflammatory agents, such as anti-rheumatoid arthritis drugs.

Adenosine A3 receptor antagonists

A pharmaceutical composition for antagonizing adenosine at adenosine A3receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be substituted is provided and can be used as a prophylactic and therapeutic agent for asthma, allergosis, inflammation, and so on.

p38MAP KINASE INHIBITORS

A 1,3-thiazole compound substituted at the 5-position by a pyridyl group optionally having substituent(s) has a superior p38 MAP kinase inhibitory activity and TNF-α production inhibitory activity.

Substituent and temperature controlled tautomerism of 2-phenacyl-pyridine: The hydrogen bond as a configurational lock of (Z)-2-(2-hydroxy-2-phenylvinyl)pyridine

2-Phenacylpyridines substituted in the benzene ring are in equilibrium with (Z)-2-(2-hydroxy-2-phenylvinyl)pyridines when dissolved in chloroform. The substituent affects significantly the tautomeric equilibrium [the amount of the enolimine form stabilized by the intramolecular hydrogen bond is 1 and 92% for R = p-N(CH2)4 and p-NO2, respectively]. The negative logarithm of the tautomeric equilibrium constant, KT, is linearly dependent on the Hammett σ substituent constants. The dependence of KT vs. temperature is exponential in character: the more electron-withdrawing is the substituent, the more distinct is the influence of temperature. Unexpectedly, the tautomer present in the crystalline state is not the same for all compounds studied (it is the ketimine one for those carrying strong electron-donor groups). Among the different ab initio methods used to calculate the enthalpy of the proton transfer in chloroform solution, MP2/6-31G** gives the best results.

Bisphosphonic acid derivatives as anti-arthritic agents

The bisphosphonates of formula (III) bicyclic bisphosphonates (V), and cyclic bisphosphonates (VII) are useful as anti-arthritic agents and do not have the side effects of anti-arthritic agents which are prostaglandin synthetase inhibitors.