100723-87-3

Upstream product

• 1558-17-4 4,6-dimethylpyrimidine 
• 611-73-4 Benzoylformic acid 
• 77767-94-3 (4,6-dimethylpyrimid-2′-yl)-trimethylammonium chloride 
• 166319-05-7 2-Oxo-3-phenyl-5,7-dimethylisoxazolo<2,3-a>pyrimidine 
• 98-88-4 benzoyl chloride 
• 25726-04-9 phenylglyoxylyl chloride 
• 22126-16-5 4,6-dimethyl-2-pyrimidinecarbonitrile 

Relevant academic research and scientific papers

DIRECT INTRODUCTION OF ACYL AND ETHOXYCARBONYL GROUPS INTO PYRIMIDINE RING THROUGH THE TRIMETHYLSTANNYL DERIVATIVES

The reactions of acylformyl chlorides with 2- and 4-trimethylstannylpyrimidine derivatives proceeded more smoothly than those of acyl chlorides giving the corresponding 2- and 4-acylpyrimidines.Employing ethyl chloroglyoxylate instead of the acylating agent yielded the ethoxycarbonylpyrimidines.Similarly, the stepwise acylation and ethoxycarbonylation of bis(trimethylstannyl)pyrimidines provided pyrimidines having two different carbon functional groups.

Visible-Light-Triggered, Metal- and Photocatalyst-Free Acylation of N-Heterocycles

A photoinduced acylation of N-heterocycles is explored. This visible-light triggered reaction occurs not only under extremely mild reaction conditions, but also does not require the presence of a photosensitizer. The mechanistic studies suggest formation of EDA complexes prompt to harness the energy from visible-light. Compatibility with a large panel of α-keto acids as acyl precursors and an array of N-heterocycles clearly showcase the synthetic potential of this handy and green acylation protocol. (Figure presented.).