100780-39-0

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 
• 148527-33-7 2-nitro-1-hydroxy-1-(4-methoxy-phenyl)-propane 
• 37629-51-9 1-methoxy-4-((E)-2-nitroprop-1-enyl)benzene 
• 2769-72-4 tert-Butyl isocyanoacetate 
• 17354-63-1 4-(2-nitro-propenyl)-anisole 

Downstream Products

• 222026-52-0 1-benzyl-3-(4-methoxy-phenyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 222026-46-2 3-(4-methoxy-phenyl)-1,4-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 263898-74-4 5-acetoxy-5-(t-butoxycarbonyl)-1,5-dihydro-4-(p-methoxyphenyl)-3-methyl-2H-pyrrol-2-one 
• 152796-97-9 4-(4-Methoxy-phenyl)-3-methyl-5-(toluene-4-sulfonyl)-1,5-dihydro-pyrrol-2-one 
• 263898-70-0 t-butyl 5-iodo-3-(p-methoxyphenyl)-4-methyl-2-pyrrolecarboxylate 

Relevant academic research and scientific papers

A New Synthesis of Pyrroles from Nitroalkenes

Nitroalkenes, or their β-acetoxynitro precursors, react with α-isocyanoacetate esters in the presence of base to give high yields of 5-unsubstituted pyrroles; some important pyrroles are easily synthesised by this method.

Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents

Polymer-supported reagents and other solid sequestering agents may be used to generate an array of 1,2,3,4-tetra-substituted pyrrole derivatives without any chromatographic purification step.