1008108-65-3Relevant academic research and scientific papers
Direct anodic (thio)acetalization of aldehydes with alcohols (thiols) under neutral conditions, and computational insight into the electrochemical formation of the acetals
Liu, Caiyan,Shen, Yongli,Xiao, Zihui,Yang, Hui,Han, Xue,Yuan, Kedong,Ding, Yi
, p. 4030 - 4034 (2019)
A versatile protocol for the production of acetals/thioacetals by means of direct electrochemical oxidation is developed here under neutral conditions, providing (thio)acetals with good functional group tolerance and a wide scope for both aldehydes and (thio)alcohols. DFT calculations reveal that direct electron transfer from the anode plays a key role in carbonyl activation during this acid free acetalization process.
Cs2CO3-initiated trifluoro-methylation of chalcones and ketones for practical synthesis of trifluoromethylated tertiary silyl ethers
Dong, Cheng,Bai, Xing-Feng,Lv, Ji-Yuan,Cui, Yu-Ming,Cao, Jian,Zheng, Zhan-Jiang,Xu, Li-Wen
, (2017)
It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economi
One-pot synthesis of α-trifluoromethylstyrenes from aryl ketones and the Ruppert–Prakash reagent
Dilman, Alexander D.,Levin, Vitalij V.
, p. 684 - 685 (2021/11/26)
A new synthesis of α-trifluoromethylstyrenes from aromatic ketones and (trifluoromethyl) trimethylsilane is described. The reaction involves nucleophilic trifluoromethylation and elimination of trimethylsilanol, which are performed within one reaction fla
Anion-Initiated Trifluoromethylation by TMSCF3: Deconvolution of the Siliconate-Carbanion Dichotomy by Stopped-Flow NMR/IR
Johnston, Craig P.,West, Thomas H.,Dooley, Ruth E.,Reid, Marc,Jones, Ariana B.,King, Edward J.,Leach, Andrew G.,Lloyd-Jones, Guy C.
supporting information, p. 11112 - 11124 (2018/09/06)
The mechanism of CF3 transfer from R3SiCF3 (R = Me, Et, iPr) to ketones and aldehydes, initiated by M+X- (0.004 to 10 mol %), has been investigated by analysis of kinetics (variable-ratio stopped-flo
Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors
Rew, Yosup,Degraffenreid, Michael,He, Xiao,Jaen, Juan C.,McMinn, Dustin L.,Sun, Daqing,Tu, Hua,Ursu, Stefania,Powers, Jay P.
scheme or table, p. 3786 - 3790 (2012/07/14)
A novel series of benzenesulfonanilide derivatives of 11β-HSD1 inhibitors were identified via modification of the sulfonamide core of the arylsulfonylpiperazine lead structures. The synthesis, in vitro biological evaluation, and structure-activity relationship of these compounds are presented. Optimization of this series rapidly resulted in the discovery of compounds (S)-10 and (S)-23 (11β-HSD1 SPA IC50 = 1.8 and 1.4 nM, respectively).
Aniline sulfonamide derivatives and their uses
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Page/Page column 35, (2010/11/25)
Aniline sulfonamide derivatives according to formula I have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: where R1, R2, R3, R4, R5, Rsu
