1008304-85-5

Basic information

• Product Name: 2-chloro-6-methoxypyridin-4-amine
• Synonyms: 2-chloro-6-methoxypyridin-4-amine
• CAS NO: 1008304-85-5
• Molecular Formula: C6H7ClN2O
• Molecular Weight: 159
• Mol File: 1008304-85-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-chloro-6-methoxypyridin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-methoxypyridin-4-amine(1008304-85-5)
• EPA Substance Registry System: 2-chloro-6-methoxypyridin-4-amine(1008304-85-5)

Safety Data

• Hazardous Substances Data: 1008304-85-5(Hazardous Substances Data)

Usage

General Description

2-chloro-6-methoxypyridin-4-amine is a chemical compound with the molecular formula C6H7ClN2O. It is a derivative of pyridine and contains a chlorine atom, a methoxy group, and an amine group. 2-chloro-6-methoxypyridin-4-amine has potential applications in organic synthesis and pharmaceutical research, particularly in the development of new drugs. It may also have uses in the fields of agriculture and materials science. Due to its structure and properties, 2-chloro-6-methoxypyridin-4-amine could be a valuable building block for the synthesis of various complex organic molecules with diverse applications. However, further research is needed to fully explore its potential uses and properties.

Upstream product

• 67-56-1 methanol 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 124-41-4 sodium methylate 

Downstream Products

• 204378-34-7 4-chloro-6-methoxy-pyridine-2-carboxylic acid 
• 204378-37-0 4-chloro-6-methoxy-pyridine-2-carboxylic acid methyl ester 
• 1060810-46-9 4-bromo-6-methoxy-pyridine-2-carboxylic acid 
• 1256789-39-5 4-bromo-6-methoxy-pyridine-2-carboxylic acid methyl ester 
• 1443757-45-6 [4-(4-chloro-6-methoxy-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[2-(3-fluoro-phenyl)-2H-tetrazol-5-yl]-methanone 
• 1443759-42-9 4-amino-6-methoxy-pyridine-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis method of 4-bromo-2-chloro-6-methoxypyridine

The invention relates to the technical field of chemical synthesis, and concretely discloses a synthesis method of 4-bromo-2-chloro-6-methoxypyridine, according to the method, 4-bromo-2-chloro-6-methoxypyridine is used as a starting raw material, under the action of a catalyst, through methoxy substitution, and a 4-amino-2-chloro-6-methoxypyridine key intermediate with high yield is obtained, andthen diazotization bromination is carried out to obtain the target product 4-bromo-2-chloro-6-methoxypyridine. The 4-bromine-2-chloro-6-methoxypyridine is an important intermediate for drug synthesis,but the synthetic route of 4-bromine-2-chloro-6-methoxypyridine, especially the synthetic route suitable for commercial mass production, is not reported. The synthetic route of the compound is provided for the first time, the method is particularly suitable for commercial mass production, and the 4-bromine-2-chloro-6-methoxypyridine is prepared with high yield and high purity.

COMPOUNDS

Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis(ALS).

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. R1, R2, R3, R4, Q have meanings given in the description.