100858-24-0

Upstream product

• 100858-20-6 de-A,B-8β-(benzoyloxy)-25-<(methoxymethyl)oxy>cholest-23-yn-22-ol 
• 100858-22-8 (22R,23Z)-de-A,B-8β-(benzoyloxy)-25-<(methoxymethyl)oxy>cholest-23-en-ol 
• 138079-57-9 Benzoic acid (1R,3aR,4S,7aR)-1-((E)-(1R,4S)-5-hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-octahydro-inden-4-yl ester 
• 107-30-2 chloromethyl methyl ether 
• 100858-23-9 (22R,23Z)-de-A,B-8β-(benzoyloxy)-25-<(methoxymethyl)oxy>-22-<(phenylcarbamoyl)oxy>cholest-23-ene 
• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 64190-53-0 (S)-2-((1R,3aR,4S,7aR)-4-(benzoyloxy)-7a-methyloctahydro-1H-inden-1-yl)propyl benzoate 
• 66774-70-7 (8S,20S)-des-A,B-8-benzoyloxy-20-(hydroxymethyl)-pregnane 
• 66774-71-8 Benzoic acid (1R,3aR,4S,7aR)-7a-methyl-1-((S)-1-methyl-2-oxo-ethyl)-octahydro-inden-4-yl ester 
• 50-14-6 Calciferol 

Downstream Products

• 21343-40-8 ercalcidiol 
• 100858-28-4 25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether 
• 98830-20-7 25-hydroxydihydrotachysterol₂ 
• 100858-26-2 (22E,24S)-de-A,B-25-<(methoxymethyl)oxy>ergost-22-en-8-one 

Relevant academic research and scientific papers

25-Hydroxydihydrotachysterol2. An innovative synthesis of a key metabolite of dihydrotachysterol2

A new synthesis of 25-hydroxydihydrotachysterol2 is described. The hydroxylated side-chain is constructed stereoselectively using a chiral Wittig reagent. The A-ring synthon is introduced utilising the Wittig-Horner method as developed by Lythgoe et al. The preparation of the metabolite is carried out in 18 steps.

Studies on the Synthesis of Side-Chain Hydroxylated Metabolites of Vitamin D. 2. Stereocontrolled Synthesis of 25-Hydroxyvitamin D2

An efficient synthesis of 25-hydroxyvitamin D2 is described.The chiral center at C-24 was introduced by the stereospecific and regioselective displacement of an allylic carbamate by a cuprate.The triene system was assembled by Horner-Wittig coupling of ke