100866-66-8

Upstream product

• 103-19-5 di(p-tolyl) disulfide 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 17530-83-5 4-tolyl(4'-nitrobenzyl)sulfoxide 
• 619-73-8 4-nitrobenzyl chloride 
• 624-31-7 4-tolyl iodide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 2943-42-2 di(4-methyl)phenylthiosulfonate 
• 2767-70-6 (p-nitrobenzyl)triphenylphosphonium bromide 
• 26798-33-4 (p-nitrophenyl)methanethiol 
• 106-45-6 para-thiocresol 
• 100-14-1 4-nitrobenzyl chloride 

Downstream Products

• 17530-83-5 4-tolyl(4'-nitrobenzyl)sulfoxide 
• 61081-32-1 1-nitro-4-(4-tolylsulfonylmethyl)benzene 
• 1210452-12-2 (S)-4-nitrobenzyl p-tolyl sulfoxide 

Relevant academic research and scientific papers

Fe3O4@SiO2-copper sucrose xanthate as a green nanocatalyst for N-, O- and S-arylation

Formation of C(sp2)–X bonds was carried out using a Fe3O4@SiO2-copper(I) sucrose xanthate nanoparticle catalyst with the aid of the copper(I) xanthate moiety in the catalyst which was prepared from the reaction between sucrose and carbon disulfide through an alkaline medium via the traditional Zeise approach. Various techniques were employed for the characterization of these novel nanoparticles. Three sorts of heteroatoms, N, O and S, successfully underwent heteroatom arylation to produce secondary or tertiary amines, ethers and thioethers, respectively.

Unusual Application for Phosphonium Salts and Phosphoranes: Synthesis of Chalcogenides

A novel strategy for the synthesis of sulfides and selenides from phosphonium salts and thio- or selenesulfonates, commercially available compounds, is described. When phosphoranes were used in the reaction, different products were obtained. The methodology does not require the use of metals, reactive species, or anhydrous conditions to be performed.

Efficient dehydrative alkylation of thiols with alcohols catalyzed by alkyl halides

Alcohols can be efficiently converted into the useful thioethers by a transition metal- and base-free dehydrative S-alkylation reaction with thiols or disulfides by employing alkyl halides as the effective catalyst. This simple and efficient method is a green and practical way for the preparation of thioethers, as it tolerates a wide range of substrates such as aryl and alkyl thiols, as well as benzylic, allylic, secondary, tertiary, and even the less reactive aliphatic alcohols.

One-Pot Copper-Catalysed Thioetherification of Aryl Halides Using Alcohols and Lawesson's Reagent in Diglyme

A new protocol for the thioetherification of structurally varied alcohols with aryl halides using Lawesson's reagent, catalysed by copper(I) iodide, and using diglyme as a safe solvent was developed. Using this method, the reactions of aryl halides proceeded efficiently, and the desired sulfides were obtained in high to excellent yields. The method uses alcohols as starting materials, which is a significant advantage over methods that start from thiols. Alcohols are widely commercially available in a much greater structural diversity than thiols, and they are also nontoxic and not foul-smelling. A reaction mechanism was proposed. A copper-catalysed method for the thioetherification of alcohols with aryl halides using Lawesson's reagent was developed.

Stereoselective control by face-to-face versus edge-to-face aromatic interactions: The case of C3-TiIV amino trialkolate sulfoxidation catalysts

The stereoselective oxidation of differently functionalised benzyl phenyl sulfides has been examined by using enantiopure TiIV trialkanolamine complexes. These complexes efficiently catalyse the sulfoxidation with good stereoselectivities. The

Mild and efficient deoxygenation of sulfoxides to sulfides with triflic anhydride/potassium iodide reagent system

It was found that the combination of triflic anhydride/potassium iodide was an effective promoter for the deoxygenation of sulfoxides and gave the corresponding sulfides in excellent yield in acetonitrile at room temperature. It is worth mentioning that this reagent system is chemoselective and tolerates various functional groups, such as alkene, ketone, ester, aldehyde, acid, and oxime. Georg Thieme Verlag Stuttgart.

ZrCl4 dispersed on dry silica gel provides a useful reagent for S-alkylation of thiols with alcohols under solvent-free conditions

ZrCl4 which is commercially available and not a costly compound, is a relatively safe chemical [LD50 [ZrCl4, oral rat] = 1688 mg Kg]. In this report we describe the use of ZrCl4 dispersed on dry silica gel as an efficient reagent for the efficient preparation of thioethers from thiols with alcohols under solvent-free conditions.

Ruthenium-catalyzed [2+2] cycloadditions of alkynyl sulfides and alkynyl sulfones

Ruthenium-catalyzed [2+2] cycloadditions of bicyclic alkenes with alkynyl sulfides and alkynyl sulfones were investigated. The sulfide and sulfone moieties were found to be compatible with the Ru-catalyzed cycloadditions, giving the corresponding cyclobut

Synthesis of organic sulfides via Zn/AlCl3 system in aqueous media

An efficient procedure for preparation of various sulfides has been introduced through a simple reaction of disulfides with suitable alkyl or aryl halides which is promoted by commercial zinc powder in the presence of AlCl3 in aqueous media at 65°C.

Synthesis of organic sulfides from disulfides using a Zn/AlCl3 system in aqueous media

A convenient procedure for the synthesis of organic sulfides from different alkyl halides and aryl disulfides by a Zn/AlCl3 system in aqueous media is presented.