100914-76-9

Basic information

• Product Name: 4,6-DICHLORO-2-PHENYLQUINOLINE
• Synonyms: 4,6-DICHLORO-2-PHENYLQUINOLINE
• CAS NO: 100914-76-9
• Molecular Formula: C₁₅H₉Cl₂N
• Molecular Weight: 274.14
• Mol File: 100914-76-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 399.6°C at 760 mmHg
• Flash Point: 227.8°C
• Appearance: /
• Density: 1.331g/cm³
• Vapor Pressure: 3.11E-06mmHg at 25°C
• Refractive Index: 1.665
• CAS DataBase Reference: 4,6-DICHLORO-2-PHENYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-2-PHENYLQUINOLINE(100914-76-9)
• EPA Substance Registry System: 4,6-DICHLORO-2-PHENYLQUINOLINE(100914-76-9)

Safety Data

• Hazardous Substances Data: 100914-76-9(Hazardous Substances Data)

Usage

General Description

4,6-Dichloro-2-phenylquinoline is a chemical compound with the molecular formula C15H9Cl2N. It is a quinoline derivative and belongs to the class of organic compounds known as chloroquinolines. 4,6-DICHLORO-2-PHENYLQUINOLINE is commonly used in the field of medicinal chemistry and pharmacology as it exhibits potential therapeutic properties. It has shown to have antibacterial and antifungal activities and has been studied for its potential as a drug against various infectious diseases. Additionally, 4,6-Dichloro-2-phenylquinoline has also been investigated for its potential as an anticancer agent due to its inhibitory effects on cancer cell growth. Overall, this chemical shows promise for various pharmaceutical applications.

InChI:InChI=1/C15H9Cl2N/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-9H

Upstream product

• 17282-72-3 6-chloro-2-phenyl-quinolin-4-ol 
• 106-47-8 4-chloro-aniline 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Relevant articles and documents

ANTIMALARIAL COMPOUNDS

Antimalarial compounds of the formula: in which n is 1 or 2; X is C or N; R1 is a moiety comprising a secondary amine and a tertiary amine joined by a C2 to C4 alkyl chain; and R2 is CF3, F, or H, or an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof. Pharmaceutical compounds including the antimalarial compounds. Methods of treating or preventing malaria comprising administering an effective amount of the antimalarial compounds.

Quinoline derivatives as antitubercular/antibacterial agents

A number of quinoline derivatives of known antibacterial agents have been prepared and tested against the micro-organisms S. coli, S. paratyphi B, S. aureus and in particular against Mycobacterium tuberculosis H37-Rv. It has not been possibfe to establish correlation between antibacterial and antitubercular activities of these compounds. However, the antitubercular effect at MIC of 5 μg/mL against H37Rv shows that many modified compounds are more inhibitory than the parent agents such as 3-aminophenol, sulphamethoxazole, sulphaphenazole, sulphathiazole and monoacetyldapsone; among these the most effective are those with substituents such as 6-methyl, 6-chloro, 6-ethoxy-, or 8-methoxy functions in quinoline moiety.