101024-95-7Relevant academic research and scientific papers
Tandem Synthesis of 1,3-Disubstituted Naphthalenes via TfOH-Promoted Directed-Aldol and Friedel-Crafts Reactions
Li, Hongchen,Shan, Lidong,Min, Lin,Weng, Yunxiang,Wang, Xinyan,Hu, Yuefei
, p. 15011 - 15019 (2021/10/25)
A TfOH-promoted tandem synthesis of 1,3-disubstituted naphthalenes is developed via a directed-aldol reaction and a Friedel-Crafts reaction. Two new C-C bonds and one new benzene ring are created efficiently in one pot due to the discovery of a TfOH-promoted highly chemoselective directed-aldol reaction between two different ketones with α-hydrogens.
Ligand-Free and Solvent-Free Synthesis of 1,3-Disubstituted Naphthalenes through Stille Coupling
Mkpenie, Victor,Rohand, Taoufik,Sbi, Sanae,Tanemura, Kiyoshi
supporting information, p. 903 - 906 (2020/05/28)
A variety of 1,3-disubstituted naphthalenes have been prepared by palladium-catalyzed annulation of (o-ethynylphenyl)acetyl chloride with design of a new synthetic strategy by Stille coupling using functionalized organostannanes. The method affords excellent yields of the substituted naphthalenes and accommodates a wide variety of functional groups under mild conditions. Mechanistic studies show intramolecular cyclization as a major step following C-C bond coupling.
Reaction of Benzyltriphenylarsonium Ylides with α,β-Unsaturated Ketones: Synthesis of 1,3-Diarylnaphthalenes
Gupta, K. C.,Pathak, P. K.,Saxena, B. K.
, p. 783 - 784 (2007/10/02)
Benzyltriphenylarsonium bromide (I) reacts with substituted benzylideneacetophenones (III) in gl. acetic acid in the presence of anhyd.ZnCl2 and sodium acetate to give 1,3-diarylnaphthalenes (V).Their structures have been established by elemental analysis
