101048-46-8

Basic information

• Product Name: (E)-1,1,1-trifluoro-4-(p-fluorophenyl)-3-buten-1-one
• Synonyms: (E)-1,1,1-trifluoro-4-(p-fluorophenyl)-3-buten-1-one
• CAS NO: 101048-46-8
• Molecular Weight: 218.151
• Mol File: 101048-46-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (E)-1,1,1-trifluoro-4-(p-fluorophenyl)-3-buten-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1,1,1-trifluoro-4-(p-fluorophenyl)-3-buten-1-one(101048-46-8)
• EPA Substance Registry System: (E)-1,1,1-trifluoro-4-(p-fluorophenyl)-3-buten-1-one(101048-46-8)

Safety Data

• Hazardous Substances Data: 101048-46-8(Hazardous Substances Data)

Upstream product

• 421-50-1 1,1,1-trifluoro-2-propanone 
• 459-57-4 4-fluorobenzaldehyde 
• 405-99-2 para-fluorostyrene 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 948056-76-6 1,1,1-trifluoro-3-iodo-4-(4-fluorophenyl)but-3-en-2-one 
• 1017536-02-5 (S)-4-(trifluoromethyl)-4-hydroxy-6-(p-fluorophenyl)hex-5-en-2-one 
• 1227671-27-3 1,1,1-trifluoro-4-(4-fluorophenyl)-4-(1H-indol-3-yl)butan-2-one 
• 1201890-42-7 2,2,2-trifluoro-1-((2S,3R)-3-(4-fluorophenyl)oxiran-2-yl)ethane-1,1-diol 
• 170569-88-7 mavacoxib 
• 1033547-40-8 C₁₄H₈F₇N 
• 251442-99-6 1-(4-aminosulphonylphenyl)-4,5-dihydro-5-(4-fluorophenyl)-3-trifluoromethyl-1H-pyrazole 
• 251443-00-2 4,5-dihydro-5-(4-fluorophenyl)-1-(4-methylsulphonylphenyl)-3-trifluoromethyl-1H-pyrazole 
• 948057-02-1 (E)-3-[2-(4-chlorophenyl)ethynyl]-1,1,1-trifluoro-4-(4-fluorophenyl)but-3-en-2-ol 
• 948056-94-8 (E)-1,1,1-trifluoro-4-(4-fluorophenyl)-3-(2-phenylethynyl)but-3-en-2-ol 
• 948056-86-8 (Z)-1,1,1-trifluoro-4-(4-fluorophenyl)-3-iodobut-3-en-2-ol 

Relevant articles and documents

Radical Trifluoroacetylation of Alkenes Triggered by a Visible-Light-Promoted C–O Bond Fragmentation of Trifluoroacetic Anhydride

We report a mild and operationally simple trifluoroacylation strategy of olefines, that utilizes trifluoroacetic anhydride as a low-cost and readily available reagent. This light-mediated process is fundamentally different from conventional methodologies and occurs through a trifluoroacyl radical mechanism promoted by a photocatalyst, which triggers a C?O bond fragmentation. Mechanistic studies (kinetic isotope effects, spectroelectrochemistry, optical spectroscopy, theoretical investigations) highlight the evidence of a fleeting CF3CO radical under photoredox conditions. The trifluoroacyl radical can be stabilized under CO atmosphere, delivering the trifluoroacetylation product with higher chemical efficiency. Furthermore, the method can be turned into a trifluoromethylation protocol by simply changing the reaction parameters. Beyond simple alkenes, this method allows for chemo- and regioselective functionalization of small-molecule drugs and common pharmacophores.

A Weinreb amide approach to the synthesis of trifluoromethylketones

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF3) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.

Reaction of 1,2-unsaturated trifluoromethyl ketones and their conversion to 1-(trifluoromethyl)furan derivatives

A novel synthetic approach leading to 1-(trifluoromethyl)furan derivatives is reported. 4-Aryl-1,1,1-trifluorobut-3-en-2-one was iodinated and subsequently reduced to give the corresponding alcohol. The resultant iodo compound was then subjected to coupli