101080-58-4

Usage

Uses

Used in Research and Development Labs:
2-Chloro-6-methylbenzamide is utilized as a research compound for studying its chemical properties and potential applications in various fields. Its unique structure and reactivity make it a valuable tool for understanding the behavior of similar compounds and developing new synthetic pathways.
Used in Chemical Synthesis:
In the chemical industry, 2-chloro-6-methylbenzamide is employed as a building block or intermediate in the synthesis of more complex organic compounds. Its reactive amide group allows for various chemical reactions, enabling the creation of a wide range of products with diverse applications.
Used in Pharmaceutical Development:
Although not extensively studied, 2-chloro-6-methylbenzamide may have potential applications in the pharmaceutical industry. Its unique structure and reactivity could be harnessed to develop new drugs or improve existing ones. Further research is required to explore its potential in this field.
Used in Material Science:
The properties of 2-chloro-6-methylbenzamide, such as its molecular weight and chemical structure, may make it suitable for use in material science applications. It could potentially be incorporated into the development of new materials with specific properties, such as improved stability or enhanced reactivity.

InChI:InChI=1/C8H8ClNO/c1-5-3-2-4-6(9)7(5)8(10)11/h2-4H,1H3,(H2,10,11)

Upstream product

• 6575-09-3 2-chloro-6-methyl-benzonitrile 
• 1885-76-3 2-cyano-3-nitrotoluene 
• 56043-01-7 2-amino-6-methylbenzonitrile 
• 87-63-8 2-chloro-6-methylaniline 
• 118-90-1 ortho-methylbenzoic acid 
• 933-88-0 ortho-toluoyl chloride 
• 527-85-5 o-Methylbenzamid 

Downstream Products

• 21327-86-6 2-chloro-6-methylbenzoic acid 
• 89894-44-0 2-chloro-6-methylbenzoyl chloride 

Relevant academic research and scientific papers

Copper-Mediated sp 2 C-H Chlorination with Trichloroacetamide Using a Removable Directing Group

2-Aminophenyl-1 H -pyrazole was discovered as a removable, bidentate directing group for copper-mediated aerobic oxidative sp 2 C-H bond chlorination employing trichloroacetamide as a new chlorine source. When Cu(OAc) 2 was employed as the copper source, 1,1,3,3-tetramethylguanidine (TMG) as an organic base, the reaction, optimally carried out overnight in DMSO at 80 °C in open air, produced a variety of mono- and dichlorinated products in moderate to excellent yields. This directing group can be removed oxidatively with cerium ammonium nitrate (CAN).

Acid-promoted palladium(II)-catalyzed ortho-halogenation of primary benzamides: En route to halo-arenes

Br?nsted acid-promoted palladium(II)-catalyzed regioselective installation of halogens (Br, Cl, and I) to the aromatic ring of benzamide derivatives has been achieved using primary amides. A wide variety of benzamides were compatible under established conditions to afford the halogenated products without installing any external auxiliary. Mild reaction conditions, use of primary amide as a directing group, external additive-free conditions, and gram-scale reaction are some appealing features of this protocol. Detailed experimental results revealed that Br?nsted acid plays a critical role in this transformation.

TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.