89894-44-0

Usage

Uses

Used in Agrochemical Production:
Benzoyl chloride, 2-chloro-6-methyl(9CI) is utilized as a key intermediate in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals designed to protect crops and enhance yield.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, Benzoyl chloride, 2-chloro-6-methyl(9CI) serves as a vital component in the synthesis of various drugs. Its reactivity and functional group compatibility make it suitable for creating a range of medicinal compounds.
Used in Dye Manufacturing:
Benzoyl chloride, 2-chloro-6-methyl(9CI) is also employed in the manufacturing of dyes, where it contributes to the creation of colorants used across different industries, including textiles, plastics, and printing inks.
Used as a Reagent in Organic Synthesis:
Benzoyl chloride, 2-chloro-6-methyl(9CI) is used as a reagent in organic synthesis, facilitating a variety of chemical reactions that are essential for the production of complex organic molecules.
Safety Considerations:
Given its highly corrosive nature, Benzoyl chloride, 2-chloro-6-methyl(9CI) requires careful handling to prevent skin, eye, and respiratory irritation. Proper safety measures and personal protective equipment are essential when working with Benzoyl chloride, 2-chloro-6-methyl- (9CI).

Upstream product

• 87-63-8 2-chloro-6-methylaniline 
• 118-91-2 ortho-chlorobenzoic acid 
• 1194-64-5 2-chloro-6-methylbenzaldehyde 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 85070-46-8 2-chloro-6-methylbenzenediazonium tetrafluoroborate 
• 69190-56-3 2-bromo-1-chloro-3-methylbenzene 
• 99585-14-5 methyl 2-chloro-6-methylbenzoate 
• 5100-98-1 1-chloro-2-iodo-3-methylbenzene 
• 101080-58-4 2-chloro-6-methylbenzamide 
• 6575-09-3 2-chloro-6-methyl-benzonitrile 
• 21327-86-6 2-chloro-6-methylbenzoic acid 

Downstream Products

• 99585-14-5 methyl 2-chloro-6-methylbenzoate 
• 220847-10-9 N-[(2-Chloro-6-methylphenyl)carbonyl]-4-nitro-L-phenylalanine methyl ester 
• 1224962-80-4 4-(4-nitrobenzylidene)-2-(2-chloro-6-methylphenyl)-5(4H)-oxazolone 
• 1224962-95-1 4-(4-methoxybenzylidene)-2-(2-chloro-6-methylphenyl)-5(4H)-oxazolone 
• 1224962-92-8 C₁₂H₁₂ClNO₄ 
• 1224962-78-0 2-chloro-6-methyl-hippuric acid 
• 1420829-86-2 C₂₃H₁₇ClN₄OS 
• 1420829-90-8 C₂₆H₁₉N₇OS 
• 1420830-49-4 (S)-8-chloro-3-(1-(2-chloro-3-nitropyridine-4-ylamino)ethyl)-2-phenylisoquinolin-1(2H)-one 
• 1420830-50-7 C₂₂H₁₇ClN₄O₃S 
• 1420830-51-8 C₂₂H₁₉ClN₄OS 
• 1420830-03-0 C₂₇H₂₁N₇OS 
• 1420829-02-2 C₂₂H₁₆ClN₅OS 
• 1420829-04-4 C₂₆H₂₁N₇OS 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONALS, AND METHODS FOR TREATING T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

In an aspect, the disclosure provides for compounds (II), compositions, and methods of administering the compounds and compositions to a patient in need thereof. In another aspect, the disclosure relates to compounds and compositions for treating cancer,

HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as: cancers, autoimmune diseases, and respiratory diseases.

Pyrimido oxazine derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for use in preventing or treating PI3 kinase related diseases

The present invention relates to pyrimido oxazine derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an effective component for preventing or treating PI3 kinase-related diseases. The pyrimido oxazine derivatives according to the present invention have excellent selective inhibitory effects on PI3 kinase, and thus may be beneficially used in preventing or treating PI3 kinase-related diseases such as the following: cancers including blood cancer, ovarian cancer, cervical cancer, breast cancer, large intestine cancer, liver cancer, stomach cancer, pancreatic cancer, colon cancer, periotoneal cancer, skin cancer, bladder cancer, prostate cancer, lung cancer, osteosarcoma, fibrous tumor, and brain tumor; autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, hyperthyroidism, myasthenia gravis, Crohnandprime;s disease, ankylosing spondylitis, psoriasis, pernicious anemia, and Sjogrenandprime;s syndrome; and respiratory diseases including chronic obstructive pulmonary disease (COPD), rhinitis, asthma, chronic bronchitis, chronic pulmonary inflammatory diseases, silicosis, pulmonary sarcoidosis, pleuritis, alveolitis, vasculitis, emphysema, pneumonia, and bronchiectasis.COPYRIGHT KIPO 2017

Dihydropteridin-one derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for use in preventing or treating PI3 kinase related diseases

The present invention relates to dihydropteridin-one derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an effective component for preventing or treating PI3 kinase-related diseases. According to the present invention, the dihydropteridin-one derivatives have excellent selective inhibitory effects on PI3 kinase, and thus may be beneficially used in preventing or treating PI3 kinase-related diseases such as the following: cancers including blood cancer, ovarian cancer, cervical cancer, breast cancer, large intestine cancer, liver cancer, stomach cancer, pancreatic cancer, colon cancer, periotoneal cancer, skin cancer, bladder cancer, prostate cancer, lung cancer, osteosarcoma, fibrous tumor, and brain tumor; autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, hyperthyroidism, myasthenia gravis, Crohnandprime;s disease, ankylosing spondylitis, psoriasis, pernicious anemia, and Sjogrenandprime;s syndrome; and respiratory diseases including chronic obstructive pulmonary disease (COPD), rhinitis, asthma, chronic bronchitis, chronic pulmonary inflammatory diseases, silicosis, pulmonary sarcoidosis, pleuritis, alveolitis, vasculitis, emphysema, pneumonia, and bronchiectasis.COPYRIGHT KIPO 2017

QUINAZOLINE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides a quinazoline derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The quinazoline derivative or its pharmaceutically acceptable salt has a selective inhibitory activity against the phosphatidylinositol 3-kinase delta subunit, and therefore can be usefully applied for preventing or treating cancer, along with avoiding side effects such as lymphopenia-associated inflammatory responses.

SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Nickel or phenanthroline mediated intramolecular arylation of sp 3 C-H bonds using aryl halides

The development of the intramolecular arylation of sp3 C-H bonds adjacent to nitrogen using aryl halides is described. Arylation was accomplished using either Ni(COD)2 or 1,10-phenanthroline in substoichiometric amounts, and the reaction conditions were applied to a variety of electronically differentiated benzamide substrates. Preliminary studies suggest a mechanism involving aryl and alkyl radical intermediates.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions of formulae (I), (XI) and (XII) as PI3 kinase modulators and their use in the treatment of diseases such as cancer.