101085-03-4

Basic information

• Product Name: Benzoic acid, 2-bromo-4-hydroxy-, methyl ester
• Synonyms: 2-bromo-4-hydroxybenzoic acid methyl ester;Benzoic acid,2-bromo-4-hydroxy-,methyl ester;2-Brom-4-hydroxy-benzoesaeure-methylester
• CAS NO: 101085-03-4
• Molecular Formula: C8H7BrO3
• Molecular Weight: 231.046
• Mol File: 101085-03-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 310.6±22.0 °C(Predicted)
• Density: 1.627±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzoic acid, 2-bromo-4-hydroxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-bromo-4-hydroxy-, methyl ester(101085-03-4)
• EPA Substance Registry System: Benzoic acid, 2-bromo-4-hydroxy-, methyl ester(101085-03-4)

Safety Data

• Hazardous Substances Data: 101085-03-4(Hazardous Substances Data)

Upstream product

• 17100-65-1 2-bromo-4-methoxybenzoic acid methyl ester 
• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 98545-64-3 methyl-2-bromo-4-aminobenzoate 
• 100959-22-6 methyl 2-bromo-4-nitrobenzoate 
• 67-56-1 methanol 
• 28547-28-6 2-bromo-4-hydroxybenzoic acid 
• 22532-60-1 2-bromo-4-hydroxybenzaldehyde 

Downstream Products

• 17100-65-1 2-bromo-4-methoxybenzoic acid methyl ester 
• 1440546-78-0 2-((2-acetamido-5-methoxyphenyl)ethynyl)-4-methoxy-N-methylbenzamide 
• 1440546-89-3 methyl 2-((2-acetamido-5-methoxyphenyl)ethynyl)-4-methoxybenzoate 
• 1440546-80-4 2-((2-Acetamido-5-methoxyphenyl)ethynyl)-4-methoxybenzoic acid 
• 1440546-79-1 methyl 2-((2-amino-5-methoxyphenyl)ethynyl)-4-methoxybenzoate 
• 138408-62-5 methyl 4-hydroxy-2-vinylbenzoate 
• 1613316-32-7 C₁₇H₁₅BrO₅ 
• 1613316-35-0 C₂₈H₃₁NO₆S₂ 
• 1613316-01-0 C₂₀H₁₆O₆ 
• 1613316-00-9 C₂₀H₁₆O₆ 
• 1613315-98-2 C₂₀H₁₆O₅S 
• 1613315-96-0 C₂₀H₁₆O₅S 
• 1613315-90-4 C₂₁H₁₈O₆ 
• 1613315-88-0 C₂₁H₁₈O₆ 

Relevant articles and documents

Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity

The dramatic increase in the prevalence of multi-drug resistant Gram-negative bacterial infections and the simultaneous lack of new classes of antibiotics is projected to result in approximately 10 million deaths per year by 2050. We report on efforts to target the Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein that transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. We demonstrate the improvement of a high throughput screening hit into compounds with on-target single digit micromolar (μM) minimum inhibitory concentrations against wild-type uropathogenic Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae. A 2.98 ? resolution X-ray crystal structure of MsbA complexed with an inhibitor revealed a novel mechanism for inhibition of an ABC transporter. The identification of a fully encapsulated membrane binding site in Gram-negative bacteria led to unique physicochemical property requirements for wild-type activity.

Imidazole-containing condensed tricyclic compound and application thereof

The invention discloses an imidazole-containing condensed tricyclic compound adopting the structure as shown in the formula (I) or pharmaceutically acceptable salts, stereisomers or prodrug molecules thereof. The imidazole-containing condensed tricyclic compound has the IDO1 activity regulation function, can enhance T-cell activation through blocking immune checkpoints IDO1, is used for treating IDO1-mediated immunosuppression, and therefore, can become an effective medicine for treating malignant tumors. When used together with checkpoint protein anti-body drugs or other anti-cancer drugs, the imidazole-containing condensed tricyclic compound can enhance the anti-cancer effect. Meanwhile, the imidazole-containing condensed tricyclic compound has the potential of effectively treating IDO1 abnormity related immunosuppressive diseases and has a high application value.

Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold

In order to mimic amphipathic α-helices, a novel scaffold based on a 1,2-diphenylacetylene was designed. NMR and computational modeling confirmed that an intramolecular hydrogen bond favors conformations of the 1,2-diphenylacetylene that allow for accurat