17100-65-1Relevant academic research and scientific papers
Atropisomeric bisoxazoline ligands with a bridge across the 5,5′-position of biphenyl for asymmetric catalysis
Wang, Feijun,Zhang, Yong Jian,Wei, Hao,Zhang, Jiaming,Zhang, Wanbin
, p. 4083 - 4086 (2007)
A new family of atropisomeric bisoxazoline ligands 2 with a bridge across the 5,5′-position of biphenyl has been developed. The axial chirality of this type of ligands can be retained by macro-ring strain produced by 5,5′-linkage of biphenyls even without
Highly enantioselective Pd(II)-catalyzed Wacker-type cyclization of 2-allylphenols by use of bisoxazoline ligands with axis-unfixed biphenyl backbone
Wang, Feijun,Zhang, Yong Jian,Yang, Guoqiang,Zhang, Wanbin
, p. 4179 - 4182 (2007)
A series of axis-unfixed bisoxazoline ligands with different steric and electronic properties has been synthesized. Due to the different steric interactions, the ligands afforded only one of the two possible diastereomeric Pd(II)-complexes upon metal coor
A-D-D ’ - A type asymmetric organic photovoltaic receptor material and application thereof
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Paragraph 0021-0026, (2021/10/30)
The invention belongs to the technical field of organic photovoltaic, and particularly relates to A-D-D ' - A asymmetric organic photovoltaic receptor material and application thereof. The framework containing the non-covalent bond configuration lock is j
AMINE COMPOUND FOR INHIBITING SSAO / VAP-1 AND USE THEREOF
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Paragraph 0282; 0692-0694, (2020/12/13)
An amine compound serving as a semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, and an application thereof in medicines that can be used for treating inflammation and/or inflammation related diseases, diabetes and/or a disease related diabetes, psychiatric disorder, ischemic disease, vascular disease, fibrosis, or tissue transplant rejection.
COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION
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Page/Page column 118, (2018/10/19)
Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods.
cGAS ANTAGONIST COMPOUNDS
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Paragraph 0478, (2017/11/06)
Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
AMPHIPATHIC AND OTHER DOUBLE-SIDED ALPHA-HELIX MIMETICS BASED ON A 1,2-DIPHENYLACETYLENE SCAFFOLD
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, (2014/09/29)
Small-molecule scaffolds based on 1,2-diphenylacetylene that accurately replicate the spatial and angular projections of several side chains on both faces of an α-helix, specifically the i and i+7 side chains on one face, and the i and i+2 side chains on the other. The amphipathic α-helix mimetic can be used to disrupt disease-promoting protein-protein interactions that are mediated by α-helices.
Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold
Jung, Kwan-Young,Vanommeslaeghe, Kenno,Lanning, Maryanna E.,Yap, Jeremy L.,Gordon, Caryn,Wilder, Paul T.,Mackerell, Alexander D.,Fletcher, Steven
, p. 3234 - 3237 (2013/07/26)
In order to mimic amphipathic α-helices, a novel scaffold based on a 1,2-diphenylacetylene was designed. NMR and computational modeling confirmed that an intramolecular hydrogen bond favors conformations of the 1,2-diphenylacetylene that allow for accurat
SMALL MOLECULE COMPOUNDS FOR STEM CELL DIFFERENTIATION
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Page/Page column 79; 80; 81, (2010/04/25)
Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof. R1 is independently hydrogen or (C1-C6)alkyl; R2 is independently hydrogen, (C1-C6)alkyl, aryl, or heteroaryl; R2' is independently hydrogen, (C1-C6)alkyl, CF3 or C2F5; R3 is independently (C1-C6)alkyl, aryl, 2-tetrahydrofuryhnethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or R2 and R3 may be joined together to form a 5 or 6 member ring lactone; R4 is independently hydrogen, (C1-C6)alkyl, a 2- or 4-R5-substituted aromatic ring selected from a 4-R5-phenyl or a 2-R5-5-pyridyl, aryl, heteroaryl, aliphatic tertiary amine or halogen; and R5, R5', R6, R6', R7, R7' are each independently hydrogen, (C1-C6)alkyl, aryl, optionally substituted phenyl, heteroaryl, a heterocyclic ring, an aliphatic tertiary amine, or halogen.
5,5'- POSITION LINKED 1,1'- BIPHENYL AXIAL CHIRAL LIGAND AND METHOD FOR PREPARING THE SAME
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Page/Page column 4, (2009/07/03)
The present invention relates to a 5,5′-position linked 1,1′-biphenyl axis chiral ligand in chemical industry field. The present invention incorporates both the central chirality of oxazoline and the axial chirality of diphenyls. Such ligand can be used i
