10113-40-3

Basic information

• Product Name: N-(2 5-DIMETHYLPHENYL)FORMAMIDE 97
• Synonyms: N-(2 5-DIMETHYLPHENYL)FORMAMIDE 97;N-(2,5-Dimethylphenyl)formamide149.19;2',5'-FORMOXYLIDIDE
• CAS NO: 10113-40-3
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.192
• Product Categories: Amides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 10113-40-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 118-122 °C(lit.)
• Boiling Point: 310.1°Cat760mmHg
• Flash Point: 179.2°C
• Appearance: /solid
• Density: 1.075g/cm³
• Vapor Pressure: 0.000615mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: N-(2 5-DIMETHYLPHENYL)FORMAMIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2 5-DIMETHYLPHENYL)FORMAMIDE 97(10113-40-3)
• EPA Substance Registry System: N-(2 5-DIMETHYLPHENYL)FORMAMIDE 97(10113-40-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-36/39
• WGK Germany: 3
• Hazardous Substances Data: 10113-40-3(Hazardous Substances Data)

Usage

General Description

N-(2 5-DIMETHYLPHENYL)FORMAMIDE 97 is a chemical compound with the molecular formula C10H11NO. It is a formamide derivative with a 2,5-dimethylphenyl group. N-(2 5-DIMETHYLPHENYL)FORMAMIDE 97 is commonly used in organic synthesis as a reagent and building block for the preparation of various pharmaceuticals, agrochemicals, and other organic compounds. It has a purity of 97% and is typically used in research and development laboratories as well as in industrial applications. N-(2 5-DIMETHYLPHENYL)FORMAMIDE 97 is essential in the field of organic chemistry for its versatile reactivity and its role in the creation of complex organic molecules.

InChI:InChI=1/C9H11NO/c1-7-3-4-8(2)9(5-7)10-6-11/h3-6H,1-2H3,(H,10,11)

Upstream product

• 95-78-3 2,5-Dimethylaniline 
• 141-53-7 sodium formate 
• 64-18-6 formic acid 

Downstream Products

• 71119-75-0 5-methyl-o-tolyl isocyanide 
• 21354-48-3 2,5-dimethyl-N-methylaniline 
• 13730-09-1 2,5-dimethylbenzonitrile 
• 35998-04-0 N,N-dimethyl-1-(6-methyl-1H-indol-3-yl)methanamine 
• 51786-43-7 N-(2,5-dimethylphenyl)-N-methylnitrous amide 
• 20782-94-9 4-chloro-2,5-dimethylaniline 
• 30273-40-6 4-bromo-2,5-dimethylaniline 

Relevant articles and documents

Phosphotungstic acid supported on silica-coated CoFe2O4 nanoparticles: An efficient and magnetically-recoverable catalyst for N-formylation of amines under solvent-free conditions

Phosphotungstic acid (PTA) was rapidly and efficiently anchored on the surface of silica coated cobalt ferrite core to obtain a new three-component CoFe2O4@SiO2-PTA nanocomposite. The resultant composite was characterized by various techniques, including FT-IR, XRD, SEM, EDX, ICP-AES, and VSM. The as-synthesized nanocomposite was examined as catalyst for N-formylation of various amines under solvent-free conditions at room temperature. Due to the presence of magnetic core in this catalyst, it can be easily separated from the reaction media by applying an external magnetic field. The isolated catalyst can be reused for at least five successive times without significant leaching or loss of its high catalytic activity.

Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors

Bromodomain-containing Protein 4 (BRD4), an ‘epigenetic reader’, regulates chromatin structure and gene expression via recognizing and binding acetylated lysine in histones. BRD4 has become a therapeutic target for cancers because it promotes the expression of the tumor genes, such as c-Myc, NF-κB, and Bcl-2. In this study, a new series of 3-methyl-1H-indazole derivatives were designed via virtual screening and structure-based optimization. All compounds were synthesized and evaluated for their inhibitory activities to BRD4-BD1 and their antiproliferative effects in cancer cell lines. Among them, several compounds (such as 9d, 9u and 9w) exhibited strong BRD4-BD1 affinities and inhibition activities, and potently suppressed MV4;11 cancer cell line proliferation. Among them, compound 9d showed excellent selectivity for BRD4 and effectively suppressed c-Myc, the downstream protein of BRD4. This study provided new lead compounds for further biological evaluation on BRD4.