20077-92-3

Basic information

• Product Name: Ethanone, 1-(2-methyl-6-benzothiazolyl)- (9CI)
• Synonyms: Ethanone, 1-(2-methyl-6-benzothiazolyl)- (9CI);1-(2-methylbenzo[d]thiazol-6-yl)ethanone
• CAS NO: 20077-92-3
• Molecular Formula: C₁₀H₉NOS
• Molecular Weight: 191.24956
• Product Categories: BENZOTHIAZOLE
• Mol File: 20077-92-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(2-methyl-6-benzothiazolyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-methyl-6-benzothiazolyl)- (9CI)(20077-92-3)
• EPA Substance Registry System: Ethanone, 1-(2-methyl-6-benzothiazolyl)- (9CI)(20077-92-3)

Safety Data

• Hazardous Substances Data: 20077-92-3(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 105-53-3 diethyl malonate 
• 20077-89-8 6-<1-Hydroxy-ethyl>-2-methyl-benzothiazol 
• 101209-08-9 4-acetamido-3-bromoacetophenone 
• 103440-65-9 (2-methyl-benzothiazol-6-yl)-methanol 
• 20061-51-2 6-Formyl-2-methyl-benzthiazol 
• 1030373-71-7 N-(4-acetyl-2-iodophenyl)acetamide 
• 6941-28-2 2-methyl-1,3-benzothiazole-6-carboxylic acid 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 163726-70-3 1-(2-methyl-6-benzothiazolyl)-3-(N-benzyl-4-piperidinyl)-2-propen-1-one 

Relevant articles and documents

OGA INHIBITOR COMPOUNDS

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C90RF72 mutations.

A novel practical synthesis of benzothiazoles via Pd-catalyzed thiol cross-coupling

A convenient synthesis of substituted benzothiazoles from 2-bromoanilides has been accomplished. The various 2-bromoanilides were reacted with an alkyl thiolate in high yields using a palladium catalyst. The resulting sulfides were easily converted to the corresponding benzothiazoles via the simultaneous generation of thiols and condensation under basic or acidic conditions.