10131-46-1

Basic information

• Product Name: 6-benzyl-2-methylpyridine
• Synonyms: 6-benzyl-2-methylpyridine;2-Methyl-6-(phenylmethyl)pyridine;Einecs 233-368-8
• CAS NO: 10131-46-1
• Molecular Formula: C₁₃H₁₃N
• Molecular Weight: 183.24902
• EINECS: 233-368-8
• Mol File: 10131-46-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 275.1°C at 760 mmHg
• Flash Point: 111.3°C
• Appearance: /
• Density: 1.027g/cm³
• Vapor Pressure: 0.00872mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 6-benzyl-2-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-2-methylpyridine(10131-46-1)
• EPA Substance Registry System: 6-benzyl-2-methylpyridine(10131-46-1)

Safety Data

• Hazardous Substances Data: 10131-46-1(Hazardous Substances Data)

Usage

General Description

6-benzyl-2-methylpyridine is a chemical compound with the molecular formula C15H15N. It is a pyridine derivative with a benzyl group and a methyl group attached to the pyridine ring. 6-benzyl-2-methylpyridine is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has been found to exhibit antimicrobial and anti-inflammatory properties, making it potentially useful in the development of new drugs for treating infections and inflammatory conditions. Additionally, 6-benzyl-2-methylpyridine has been studied for its potential application in the development of novel materials and as a catalyst in organic synthesis reactions. However, further research is needed to fully understand its potential uses and effects.

InChI:InChI=1/C13H13N/c1-11-6-5-9-13(14-11)10-12-7-3-2-4-8-12/h2-9H,10H2,1H3

Upstream product

• 5315-25-3 2-bromo-6-methylpyridine 
• 6921-34-2 benzylmagnesium chloride 
• 67-56-1 methanol 
• 101-82-6 2-Benzylpyridine 
• 108-48-5 2,6-dimethylpyridine 
• 100-68-5 methyl-phenyl-thioether 
• 931-19-1 2-methylpyridine N-oxide 
• 78761-38-3 cinnamyl propionate 
• 100-39-0 benzyl bromide 
• 5583-23-3 2-(α-hydroxybenzyl)-6-methylpyridine 
• 108-86-1 bromobenzene 
• 1251919-66-0 potassium 2-(6-methylpyridin-2-yl)acetate 
• 100-44-7 benzyl chloride 
• 109-06-8 α-picoline 

Downstream Products

• 121360-79-0 1-Ethyl-2-benzyl-6-methylpyridine 
• 121360-78-9 2-Benzyl-1,6-dimethyl-pyridinium; iodide 
• 18103-78-1 (6-methylpyridin-2-yl)(phenyl)methanone 
• 80772-86-7 2-benzyl-6-methylpyridine N-oxide 
• 25927-44-0 2-(2,4-dinitrobenzyl)-6-methylpyridine 
• 1218989-06-0 4-methyl-N-(2-(6-methylpyridin-2-yl)-1,2-diphenylethyl)benzenesulfonamide 
• 1218989-05-9 N-(2-(6-benzylpyridin-2-yl)-1-phenylethyl)-4-methylbenzenesulfonamide 
• 1263979-85-6 C₁₃H₈⁽²⁾H₅N 

Relevant articles and documents

Copper-Catalyzed Base-Controlled Diastereoselective Synthesis of Tetraarylethanes from 2-Benzylpyridines

A highly efficient and base-controlled diastereoselective synthesis of tetraarylethanes through copper-catalyzed dehydrogenative homocoupling of readily available 2-benzylpyridines is reported. Various dl - and meso -tetraarylethanes were diastereoseletively synthesized by this new protocol, where base plays the role of the principle modulator: Grignard reagents selectively provide the C2 isomers, whereas KO t -Bu promotes the formation of the meso -tetraarylethanes. Interestingly, the presence of excess KO t -Bu generates the (E)-tetraarylethenes as the only product.

Palladium-Catalyzed Arylation of Benzylic C-H Bonds of Azaarylmethanes with Aryl Sulfides

Benzylic C-H arylation of azaarylmethanes with aryl sulfides has been developed by using a Pd-NHC catalyst and an amide base. Various azaarylmethanes and aryl sulfides were involved in the reaction to afford the corresponding diarylmethanes in good to excellent yields. Moreover, triarylmethane synthesis was accomplished through iterative arylations of 2- or 4-methylpyridine with two different aryl sulfides.

Acylation of 2-benzylpyridine N-oxides and subsequent in situ [3,3]-sigamatropic rearrangement reaction

An effective method for the acylation of 2-benzylpyridine N-oxides and their fast in situ [3,3]-sigmatropic rearrangement was reported. This transformation has a wide substrate scope under mild conditions, giving moderate to excellent yields. The application for the synthesis of chiral phenyl-2-pyridylmethanol products was briefly explored. Furthermore, an interesting example of tandem substitution and in situ [3,3]-sigamatropic rearrangement of 2-benzylpyridine N-oxide with benzenecarboximidoyl chloride was reported.