10138-46-2

Basic information

• Product Name: N-Ethylacetoacetamide
• Synonyms: N-Ethylacetoacetamide;Acetoacetyl ethanolamine;N-Ethylacetylacetamide;N-ethylaceoacetamine
• CAS NO: 10138-46-2
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.15704
• Mol File: 10138-46-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 282.1°C at 760 mmHg
• Flash Point: 135.3°C
• Appearance: /
• Density: 0.988g/cm³
• Vapor Pressure: 0.00342mmHg at 25°C
• Refractive Index: 1.426
• CAS DataBase Reference: N-Ethylacetoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethylacetoacetamide(10138-46-2)
• EPA Substance Registry System: N-Ethylacetoacetamide(10138-46-2)

Safety Data

• Hazardous Substances Data: 10138-46-2(Hazardous Substances Data)

Usage

Uses

N-Ethyl-3-oxobutanamide is a reagent used in the preparation of selective A3 Adenosine receptor antagonists.

InChI:InChI=1/C6H11NO2/c1-3-7-6(9)4-5(2)8/h3-4H2,1-2H3,(H,7,9)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 75-04-7 ethylamine 
• 674-82-8 4-methyleneoxetan-2-one 
• 109-89-7 diethylamine 
• 2343-88-6 Acetoacetylfluorid 

Downstream Products

• 15844-86-7 2-Chlor-acetessigsaeure-ethylamid 
• 22543-24-4 2,2-dichloro-acetoacetic acid ethylamide 

Relevant articles and documents

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Facile eco-friendly synthesis of novel chromeno[4,3-b]pyridine-2,5-diones and evaluation of their antimicrobial and antioxidant properties

Rapid and facile access to novel chromeno[4,3-b]pyridine-2,5-dione derivatives was achieved by a mild base catalysed reaction of 4-chloro-3-formylcoumarin and acetoacetamides in PEG-300 as recyclable solvent. The compounds were evaluated for their antimicrobial activities against 3 Gram-positive and 3 Gram-negative bacteria (Staphylococcus epidermis, Vibrio parahaemolyticus, Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Klebsiella pneumonia) with Cefotaxime control. They were further subjected to antioxidant studies using DPPH test with ascorbic acid control. While compounds 5d and 5k showed promising broad spectrum antibacterial properties against all the evaluated bacteria, compound 5g exhibited good antioxidant properties. [Figure not available: see fulltext.]