10140-87-1

Basic information

• Product Name: 1,2-Dichloroethyl acetate
• Synonyms: Ethanol,1,2-dichloro-, acetate (6CI,7CI,8CI,9CI); 1,2-Dichloroethanol acetate;1,2-Dichloroethyl acetate
• CAS NO: 10140-87-1
• Molecular Formula: C₄H₆Cl₂O₂
• Molecular Weight: 156.99524
• EINECS: 233-398-1
• Mol File: 10140-87-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 176.8 °C at 760 mmHg
• Flash Point: 72.4 °C
• Appearance: VISCOUS CLEAR LIQUID.
• Density: 1.295 g/cm3
• Vapor Pressure: 1.07mmHg at 25°C
• Refractive Index: 1.441
• CAS DataBase Reference: 1,2-Dichloroethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Dichloroethyl acetate(10140-87-1)
• EPA Substance Registry System: 1,2-Dichloroethyl acetate(10140-87-1)

Safety Data

• Hazardous Substances Data: 10140-87-1(Hazardous Substances Data)

Usage

General Description

1,2-Dichloroethyl acetate is a chemical compound with the molecular formula C4H6Cl2O2. It is a clear, colorless liquid with a sweet, fruity odor. 1,2-Dichloroethyl acetate is primarily used as an intermediate in the production of other chemicals, such as pesticides and pharmaceuticals. It is also used as a solvent in a variety of applications, including paint and ink formulations. The compound is flammable and may release toxic fumes when heated, so it should be handled with caution and stored in a cool, well-ventilated area. Additionally, exposure to 1,2-Dichloroethyl acetate can cause irritation to the skin, eyes, and respiratory system, so protective measures should be taken when working with this chemical.

InChI:InChI=1/C4H6Cl2O2/c1-3(7)8-4(6)2-5/h4H,2H2,1H3

Upstream product

• 108-05-4 vinyl acetate 
• 107-20-0 2-chloroethanal 
• 75-36-5 acetyl chloride 

Downstream Products

• 621-62-5 chloroacetaldehyde diethyl acetal 
• 99844-05-0 4-methoxy-benzaldehyde-thiazol-2-ylhydrazone 
• 63656-05-3 Benzaldehyde 2-thiazolylhydrazone 
• 100517-73-5 acetic acid-[4-(thiazol-2-ylhydrazono-methyl)-anilide] 
• 96-50-4 2-thiazolylamine 
• 6142-06-9 2-methylaminothiazole 
• 19765-35-6 2-phenylamino-1,3-selenazole 
• 127-76-4 4'-(thiazol-2-ylsulfamoyl)acetanilide 
• 107-20-0 2-chloroethanal 
• 75-36-5 acetyl chloride 
• 55484-03-2 2-(2'-furyl)pyridine 
• 33142-18-6 2-phenylaminothiazole 

Relevant articles and documents

A Continuous Flow Sulfuryl Chloride-Based Reaction - Synthesis of a Key Intermediate in a New Route toward Emtricitabine and Lamivudine

We demonstrate a continuous two-step sequence in which sulfenyl chloride is formed, trapped by vinyl acetate, and chlorinated further via a Pummerer rearrangement. These reactions produce a key intermediate in our new approach to the oxathiolane core used to prepare the antiretroviral medicines emtricitabine and lamivudine. During batch scale-up to tens of grams, we found that the sequence featured a strong exotherm and evolution of hydrogen chloride and sulfur dioxide. Keeping gaseous byproducts in solution and controlling the temperature led to better outcomes. These reactions are ideal candidates for implementation in a continuous mesoscale system for the sake of superior control. In addition, we found that fast reagent additions at controlled temperatures decreased byproduct formation. Herein we discuss the flow implementation and the final reactor design that led to a system with a 141 g/h throughput.

Kinetics of Chromic Acid Oxidation of Aliphatic Acetals in Aqueous Acetic Acid Medium

The oxidation of aliphatic acetals (prepared from aliphatic aldehydes, aliphatic alcohols, halogen substituted alcohols and aromatic alcohols) by chromic acid in aqueous acetic acid medium is first order each in and and yields the corresponding ester as the main product.Substituent effect, activation parameters and salt effects suggest that the elimination of a proton from the complex species involving the acetal and chromium is the rate-determining step.The activation enthalpies and entropies of the reactions are linearly related.