101445-85-6Relevant academic research and scientific papers
Synthesis of 3-cyanomethylated coumarins by a visible-light-mediated direct cyanomethylation of aryl alkynoates
Zhang, Wei,Yang, Chen,Pan, Yu-Liang,Li, Xin,Cheng, Jin-Pei
supporting information, p. 5788 - 5792 (2018/08/21)
A visible-light-promoted, mild, and direct cyanomethylation of aryl alkynoates has been developed. This method provides a new strategy toward the synthesis of 3-cyanomethylated coumarins via a domino radical addition/5-exo cyclization/ester migration cascade reaction in moderate to good yields at room temperature. Converting the resulting products into various molecules exhibited the synthetic utility of the present methodology.
