101458-39-3

Upstream product

• 3123-97-5 dihydro-5,5-dimethyl-2(3H)-furanone 
• 100-52-7 benzaldehyde 
• 124-38-9 carbon dioxide 
• 6662-56-2 2-Methyl-5-phenyl-4-pentyn-2-ol 
• 116145-54-1 2-(Bis-methylsulfanyl-methylene)-4-methyl-1-phenyl-pent-4-en-1-ol 
• 116145-44-9 2-(Bis-methylsulfanyl-methylene)-4-methyl-1-phenyl-pent-4-en-1-one 
• 20365-21-3 methyl 3-oxo-3-phenylpropanedithioate 
• 124957-36-4 Methyl 3-acetoxy-2-methylene-3-phenylpropanoate 
• 1199-77-5 α-methylcinnamic acid 
• 67-64-1 acetone 
• 116145-61-0 methyl 2-isobutenylcinnamate 

Downstream Products

• 66341-26-2 2(α-bromophenylmethyl)-4,4-dimethyl-2-buten-4-olide 
• 127533-09-9 3,3-Dimethyl-10-phenyl-3a,9-dihydro-3H-2-oxa-4-thia-9-aza-benzo[f]azulen-1-one 
• 127533-07-7 2-(α-anilinophenylmethylene)-4,4-dimethyl-4-butanolide 
• 127532-97-2 2-(α-hydroxyphenyl)methyl-4,4-dimethyl-2-buten-4-olide 
• 51716-58-6 2-benzoyl-4,4-dimethyl-2-buten-4-olide 

Relevant academic research and scientific papers

CO2-activation for γ-butyrolactones and its application in the total synthesis of (±)-heteroplexisolide e

An efficient nickel(0)-catalyzed highly regio- and stereoselective hydrocarboxylation of homopropargylic alcohols with ZnEt2 in the presence of CO2 (1 atm, balloon) to synthesize α-alkylidene- γ-butyrolactones is described. The catal

Facile synthesis of lactones and dihydronaphthalenes from methyl 2-isobutenyl (or 2-isopentenyl)cinnamates as the common intermediates

We prepared three different types of compounds, two α-alkylidene- γ-butyrolactones and 3,4-dihydronaphthalene-2-carboxylic acid from methyl 2-isobutenylcinnamates or methyl 2-isopentenylcinnamates as the common intermediates, which were derived from the acetates of Baylis-Hillman adducts.

Synthesis of 10-Aryl-3a,9-dihydro-1H,3H-furobenzothiazepin-1-ones

A practical synthetic route for 2-aroyl-4,4-dimehyl-2-buten-4-olides was developed. 10-Aryl-3a,9-dihydro-1H,3H-furolbenzothiazepin-1-ones were synthesized from 2-aroyl-4,4-dimethyl-2-buten-4-olides and 2-aminothiophenol in good yields.

POLARIZED KETENE DITHIOACETALS 63. STEREOSELECTIVE SYNTHESIS OF Α-YLIDENE-Γ-BUTYROLACTONES

A facile method for highly stereoselective synthesis of α-arylidene (4a-d, 4f-h and 4j) and α-ethylidene (4e,4i)-γ-butyrolactones has been developed by acid catalyzed lactonization of the corresponding α-ylidene-γ,δ-unsaturated esters 3a-j.The required es

α-ALKYLIDENE-γ-LACTONE SYNTHESIS: α-METHYL AND α-BENZYLCINNAMIC ACID DIANION ADDITION TO KETONES

α-methyl and α-benzylcinnamic acids and lithium diisopropylamide (DIPA) generate stable dianions that as addition reagents are useful for the synthesis of α-methylene- and α-benzylidene-γ-lactones.