1015609-91-2

Usage

Uses

Used in Organic Synthesis:
4-((Trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine is used as a building block in organic synthesis for the preparation of various functionalized derivatives. Its unique structure allows for the creation of a wide range of chemical compounds with diverse properties and potential applications.
Used in Materials Science:
In materials science, 4-((Trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine serves as a precursor for the synthesis of new materials with potential applications in various industries. Its structural properties make it a valuable component in the development of advanced materials with specific characteristics.
Used in Pharmaceutical Compounds Synthesis:
4-((Trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine is used as a precursor in the synthesis of pharmaceutical compounds. Its unique structure and functional groups make it a promising candidate for the development of new drugs with improved therapeutic properties.
Used in Electronics and Optoelectronics Applications:
In the field of electronics and optoelectronics, 4-((Trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine has potential applications in the development of new materials with specific electronic and optical properties. Its incorporation into these materials can lead to enhanced performance and novel functionalities.
Used in Medicinal Chemistry:
4-((Trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine is used as a scaffold in medicinal chemistry for the design of novel drug candidates. Its unique structure and functional groups provide a foundation for the development of new therapeutic agents with potential applications in various medical fields.

Upstream product

• 1066-54-2 trimethylsilylacetylene 
• 348640-06-2 4-bromo-7-azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 271-63-6 7-Azaindole 
• 319474-34-5 4-iodo-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1174296-52-6 N-tert-Butyl-2-[2-(1H-pyrrolo[2,3-b]pyridin-4-ylethynyl)-phenyl]-acetamide 
• 1174296-51-5 [2-(1H-pyrrolo[2,3-b]pyridin-4-ylethynyl)-phenyl]-acetic acid 
• 1174296-23-1 4-fluoro-2-(1H-pyrrolo[2,3-b]pyridin-4-ylethynyl)benzonitrile 
• 1243324-22-2 N-{3-[(4-ethynyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-hydroxy-methyl]-2,4-difluoro-phenyl}-4-trifluoromethyl-benzenesulfonamide 

Relevant academic research and scientific papers

A one-pot three-component synthesis of fused Spiro-Indoline/Indene derivatives derived from ethynyl azaindole by 1,3-dipolar cycloaddition reaction

A one-pot method for the simple, efficient, and environmentally benign protocol for the synthesis of Spiro-Indoline/Indene derivatives containing Aza indole moiety as a side chain is outlined. The 1,3-dipolar cycloaddition reaction of azomethine ylides derived from ethynyl Azaindole under mild conditions is accomplished. The low cost, easy availability of the starting material, and simple reaction conditions suggest the possible use of the present method for large-scale preparations.

Solution-phase parallel synthesis of ruxolitinib-derived Janus kinase inhibitors via copper-catalyzed azide-alkyne cycloaddition

A solution-phase parallel synthesis of triazole-derived ruxolitinib analogues was developed in the current study. The method employs copper-catalyzed azide-alkyne cycloaddition to build up the central triazole template. Product isolation by precipitation

Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors

Multiple lines of evidence have indicated that pyruvate kinase M2 (PKM2) is upregulated in most cancer cells and it is increasingly recognized as a potential therapeutic target in oncology. In a continuation of our discovery of lead compound 5 and SAR study, the 7-azaindole moiety in compound 5 was systematically optimized. The results showed that compound 6f, which has a difluoroethyl substitution on the 7-azaindole ring, exhibited high PKM2 activation potency and anti-proliferation activities on A375 cell lines. In a xenograft mouse model, oral administration of compound 6f led to significant tumor regression without obvious toxicity. Further mechanistic studies revealed that 6f could influence the translocation of PKM2 into nucleus, as well as induction of apoptosis and autophagy of A375 cells. More importantly, compound 6f significantly inhibited migration of A375 cells in a concentration-dependent manner. Collectively, 6f may serve as a lead compound in the development of potent PKM2 activators for cancer therapy.

PROTEIN KINASE INHIBITORS AND USE THEREOF

Disclosed are compounds according to Formula I: wherein the variables are described herein.

Multistep synthesis of a new tricyclic azaindole-based scaffold

In this Letter the synthetic pathway adopted for the preparation of a new functionalized tricyclic scaffold containing the 7-azaindole moiety is presented. An intramolecular palladium-mediated reaction is described as the crucial step for a condensed seve