319474-34-5

Basic information

• Product Name: 4-IODO-7-AZAINDOLE
• Synonyms: 4-IODO-7-AZAINDOLE;4-IODO-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 4-iodo-
• CAS NO: 319474-34-5
• Molecular Formula: C₇H₅IN₂
• Molecular Weight: 244.03
• Product Categories: Azaindoles
• Mol File: 319474-34-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 2.082
• Refractive Index: 1.788
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.08±0.40(Predicted)
• CAS DataBase Reference: 4-IODO-7-AZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-7-AZAINDOLE(319474-34-5)
• EPA Substance Registry System: 4-IODO-7-AZAINDOLE(319474-34-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 319474-34-5(Hazardous Substances Data)

Usage

General Description

"4-IODO-7-AZAINDOLE" is a chemical compound that belongs to the class of organic compounds known as aminopyrimidines and derivatives. These are organic compounds containing an amino group attached to a pyrimidine ring. 4-IODO-7-AZAINDOLE is particularly interesting due to its iodine atom, which allows it to be used as a building block in synthetic chemistry, especially in the synthesis of biologically active molecules. It is used in many applications, including use in the pharmaceutical industry for research and drug development.

InChI:InChI=1/C7H5IN2/c8-6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)

Upstream product

• 75-36-5 acetyl chloride 
• 55052-28-3 4-chloro-7-azaindole 

Downstream Products

• 940949-57-5 1-[2-deoxy-3,5-di-O-(toluoyl)-β-D-ribofuranosyl]-4-iodo-pyrrolo[2,3-b]pyridine 
• 1287240-29-2 1-[2-deoxy-3,5-di-O-(toluoyl)-β-D-ribofuranosyl]-4-[2,2'-bithien-5-yl]-pyrrolo[2,3-b]pyridine 
• 1621927-91-0 4-(2-fluorophenylethynyl)-1H-pyrrolo[2,3-b]pyridine 
• 1357588-08-9 4-[3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester 
• 1357587-86-0 N-{3-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide 
• 1357587-25-7 2,5-difluoro-N-{2-fluoro-3-[1-(1-methylpiperidin-4-yl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}benzenesulfonamide 
• 918513-52-7 4-(phenylethynyl)-1H-pyrrolo[2,3-b]pyridine 
• 1015609-91-2 4-[2-(trimethylsilyl)ethynyl]-1H-pyrrolo[2,3-b]pyridine 
• 1092579-97-9 1-(toluene-4-sulfonyl)-1H-4-iodo-pyrrolo[2,3-b]pyridine 
• 640735-23-5 4-fluoro-1H-pyrrolo[2,3-b]pyridine 
• 931411-88-0 C₁₃H₁₆N₄O 
• 931411-87-9 C₁₉H₂₁N₃ 
• 931411-84-6 4-(1-piperidyl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Cu(II)-catalyzed sulfonylation of 7-azaindoles using DABSO as SO2-Source and its mechanistic study

DABSO mediated sulfonylation of iodinated 7-azaindoles was achieved for the first time through sulfonylative Suzuki-Miyaura cross coupling (SMC) reaction under mild conditions giving good yields of sulfonylated 7-azaindole derivatives. Interestingly, control experiments suggest that present method involves in-situ generation of ArSO2 free radical followed by the key steps of SMC reaction. Scope of the reaction was explored with both electronically different and bulky group carrying boronic acids as coupling partner. The sulfonylation is scalable and occurred selectively at iodo group, irrespective of its position on azaindole. Moreover, the proposed mechanism has been supported by electron paramagnetic resonance (EPR) and density functional theory (DFT) calculations.

SUBSTITUTED ACETYLENE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4

The present invention relates to novel acetylene derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.

PROTEIN KINASE INHIBITORS AND USE THEREOF

Disclosed are compounds according to Formula I: wherein the variables are described herein.