1016-94-0

Usage

Uses

Used in Pharmaceutical Research:
2-Methylphenazine is used as an intermediate in organic synthesis and pharmaceutical research for the production of various biologically active compounds. Its diverse biological activities, including antibacterial, antimalarial, and antitumor properties, make it a promising candidate for the development of new drugs and therapies.
Used in Biological Imaging and Chemical Sensors:
Due to its unique photophysical properties, 2-Methylphenazine is used as a fluorescent probe in biological imaging and chemical sensors. This allows for the detection and monitoring of various biological processes and chemical reactions, contributing to advancements in the fields of medicine and chemistry.

InChI:InChI=1/C13H10N2/c1-9-6-7-12-13(8-9)15-11-5-3-2-4-10(11)14-12/h2-8H,1H3

Upstream product

• 98-95-3 nitrobenzene 
• 108-44-1 1-amino-3-methylbenzene 
• 108-88-3 toluene 
• 112211-53-7 2-allylamino-4'-methyldiphenylamine 
• 106-49-0 p-toluidine 

Downstream Products

• 7323-71-9 Phenazin-2-carbaldehyd 
• 26730-04-1 3-methylphenazin-5-oxide 
• 20537-31-9 2-methyl-phenazine 5,10-dioxide 
• 18450-16-3 phenazine-2-carboxylic acid 

Relevant academic research and scientific papers

Reactivity and substituent effects in the cyclization of N-aryl-2-nitrosoanilines to phenazines

Reactivity of variously substituted N-aryl-2-nitrosoanilines in the reaction of cyclization leading to phenazine derivatives, carried out in the presence of N,O-bis(trimethylsilyl)acetamide (BSA), was estimated on the base of the observed reaction times. A strong opposite effect of substituents located at position para to the nitroso group and those located para to the amino group in the side ring was observed. Mechanistic explanation, based on the electronic properties of the substituents and their mesomeric effects, was presented. The usefulness of the obtained data for the designed syntheses of phenazines was exposed.

Gas Phase Rearrangement Reactions of 2-(Arylamino)phenylaminyl Radicals

Generation of the aminyl radicals (1; X=Y=NH, R=H or Me) by flash vacuum pyrolysis leads to diphenylamines, phenazines, and aminocarbazoles. 15N-Labelling studies have shown that the diphenylamine and phenazine products arise by equilibration of the initial aminyl radical via the spirodienyl radical. (4; X=Y=NH)zi820