319478-14-3

Basic information

• Product Name: 5-BROMOCHROMAN
• Synonyms: 5-BROMOCHROMAN;5-bromo-3,4-dihydro-2H-chromene;5-bromochromane
• CAS NO: 319478-14-3
• Molecular Formula: C9H9BrO
• Molecular Weight: 213.07
• Mol File: 319478-14-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 274.6±29.0 °C(Predicted)
• Appearance: /
• Density: 1.484±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 5-BROMOCHROMAN(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMOCHROMAN(319478-14-3)
• EPA Substance Registry System: 5-BROMOCHROMAN(319478-14-3)

Safety Data

• Hazardous Substances Data: 319478-14-3(Hazardous Substances Data)

Usage

General Description

5-Bromo-2,3-dihydro-1H-chromene, also known as 5-Bromochroman, is a chemical compound that belongs to the class of benzene and substituted derivatives. It is a brominated derivative of a chroman, which is an organic compound that contains a benzene ring fused to a tetrahydropyran ring. 5-Bromochroman is commonly used in organic synthesis and pharmaceutical manufacturing as a building block for various drugs and biologically active compounds. Its chemical structure and properties make it a valuable intermediate for the synthesis of anti-inflammatory and anticancer drugs. It is also used in the production of fragrance and flavoring compounds. Moreover, it has been studied for its potential pharmacological activity and is considered to have promising prospects in the development of new pharmaceuticals.

Upstream product

• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 
• 41389-15-5 2-allyl-3-bromophenol 
• 41388-50-5 1-(allyloxy)-3-bromobenzene 
• 22532-61-2 2-bromo-6-hydroxybenzaldehyde 
• 1267362-25-3 ethyl (E)-3-(2-bromo-6-hydroxyphenyl)prop-2-enoate 
• 591-20-8 3-Bromophenol 
• 1016736-70-1 3-(3-bromophenoxy)propanenitrile 

Downstream Products

• 13849-32-6 3,4-dihydro-5-hydroxy-2H-1-benzopyran 

Relevant articles and documents

Alcohol Etherification via Alkoxy Radicals Generated by Visible-Light Photoredox Catalysis

A mechanistically divergent method is described that, employing a commercially available hypervalent iodine(III) reagent, generates alkoxy radicals from 1°, 2°, and 3° alcohols and allows their use in the functionalization of C(sp3)-H and C(sp2)-H bonds. This visible-light photoredox catalysis produces alkyl ethers via 1,5/6-hydrogen atom transfer or aryl ethers via 1,5-addition. This mild methodology provides a practical strategy for the synthesis of acetals, orthoesters, tetrahydrofurans, and chromanes.

IMIDAZO[1,2-C]PYRIMIDINE DERIVATIVES AS PRC2 INHIBITORS FOR TREATING CANCER

Disclosed are compounds that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, disclosed are compounds of Formula (I) and pharmaceutical compositions thereof, and methods of using the compounds and pharmaceutical compositions in, for example, methods of treating cancer.

PRC2 INHIBITORS

The present invention relates to compounds that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention. (Formula (I))