1017388-59-8

Basic information

• Product Name: 1-(1-(4-chlorophenyl)cyclopropyl)ethan-1-one
• Synonyms: 1-(1-(4-chlorophenyl)cyclopropyl)ethan-1-one
• CAS NO: 1017388-59-8
• Molecular Weight: 194.661
• Mol File: 1017388-59-8.mol

Chemical Properties

• CAS DataBase Reference: 1-(1-(4-chlorophenyl)cyclopropyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-(4-chlorophenyl)cyclopropyl)ethan-1-one(1017388-59-8)
• EPA Substance Registry System: 1-(1-(4-chlorophenyl)cyclopropyl)ethan-1-one(1017388-59-8)

Safety Data

• Hazardous Substances Data: 1017388-59-8(Hazardous Substances Data)

Upstream product

• 5586-88-9 1-(4-chlorophenyl)propan-2-one 
• 1878-66-6 4-chlorophenylacetic Acid 
• 92144-00-8 1-iodo-2-methylcyclobut-1-ene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 64399-27-5 1-(4-chlorophenyl)-1-cyclopropanecarbonitrile 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 1185751-98-7 1-(1-(4-chlorophenyl)cyclopropyl)-2-(pyridin-2-ylsulfonyl)ethanone 

Relevant articles and documents

Oxidative Ring Contraction of Cyclobutenes: General Approach to Cyclopropylketones including Mechanistic Insights

An original oxidative ring contraction of easily accessible cyclobutene derivatives for the selective formation of cyclopropylketones (CPKs) under atmospheric conditions is reported. Comprehensive mechanistic studies are proposed to support this novel, yet unusual, rearrangement. Insights into the mechanism ultimately led to simplification and generalization of the ring contraction of cyclobutenes using mCPBA as an oxidant. This unique and functional group tolerant transformation proceeds under mild conditions at room temperature, providing access to a new library of polyfunctionalized motifs. With CPKs being attractive and privileged pharmacophores, the elaboration of such a simple and straightforward strategy represents a highly valuable tool for drug discovery and medicinal chemistry. Additionally, the described method was employed to generate a pool of bioactive substances and key precursors in a minimum number of steps.

Bromomethyl Silicate: A Robust Methylene Transfer Reagent for Radical-Polar Crossover Cyclopropanation of Alkenes

A general protocol for visible-light-induced cyclopropanation of alkenes was developed with bromomethyl silicate as a methylene transfer reagent, offering a robust tool for accessing highly valuable cyclopropanes. In addition to α-aryl or methyl-substituted Michael acceptors and styrene derivatives, the unactivated 1,1-dialkyl ethylenes were also shown to be viable substrates. Apart from realizing the cyclopropanation of terminal alkenes, the methyl transfer reaction has been further demonstrated to be amenable to the internal olefins. The photocatalytic cyclopropanation of 1,3-bis(1-arylethenyl)benzenes was also achieved, giving polycyclopropane derivatives in excellent yields. With late-stage cyclopropanation as the key strategy, the synthetic utility of this transformation was also demonstrated by the total synthesis of LG100268.

MODULATORS FOR AMYLOID BETA

The invention relates to compounds of formula wherein the substituents are as described in claim 1. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposi