1017689-97-2

Basic information

• Product Name: 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile
• Synonyms: 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile
• CAS NO: 1017689-97-2
• Molecular Weight: 278.289
• Mol File: 1017689-97-2.mol

Chemical Properties

• CAS DataBase Reference: 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile(1017689-97-2)
• EPA Substance Registry System: 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile(1017689-97-2)

Safety Data

• Hazardous Substances Data: 1017689-97-2(Hazardous Substances Data)

Upstream product

• 2826-22-4 4-fluorobenzylidenemalononitrile 
• 100-63-0 phenylhydrazine 
• 459-57-4 4-fluorobenzaldehyde 
• 109-77-3 malononitrile 

Relevant articles and documents

Facile one-pot synthesis of 5-amino-1H-pyrazole-4-carbonitriles using alumina–silica-supported MnO2 as recyclable catalyst in water

A novel, facile, one-pot, multicomponent protocol for the synthesis of 5-amino-1H-pyrazole-4-carbonitrile derivatives has been developed using alumina–silica-supported MnO2 as recyclable catalyst in water and sodium dodecyl benzene sulphonate a

Boehmite silylpropyl amine sulfamic acid as an efficient and recyclable catalyst for the synthesis of some pyrazole derivatives

The design of biologically-active compounds is a challenging viewpoint in medicinal chemistry, and pyrazoles play a crucial role as biologically-active molecules. Methods: Up to now, a few examples have been reported for the synthesis of pyrazoles catalyz

Sodium ascorbate as an expedient catalyst for green synthesis of polysubstituted 5-aminopyrazole-4-carbonitriles and 6-amino-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles

Sodium ascorbate (SA) was used as a safe catalyst for the synthesis of 5-aminopyrazole-4-carbonitriles from the one-pot three-component cyclocondensation (3-CC) of aldehydes, phenylhydrazine, and malononitrile at 50?°C. This 3-CC proceeds in a mixture of

The synthesis of 5-amino-1H-pyrazole-4-carbonitriles by anomeric based oxidative aromatization over [CSPy]ZnCl3 as a new catalyst

4-Carboxy-1-sulfopyridin-1-ium monozinc(II) trichloride {[4CSPy]ZnCl3} as a new acidic catalyst was designed and tested on the synthesis of 5-amino-1H-pyrazole-4-carbonitriles by anomeric based oxidative aromatization. The structure of [4CSPy]Z

An environmental friendly approach for the catalyst-free synthesis of highly substituted pyrazoles promoted by ultrasonic radiation

A cost-effective, highly useful and eco-friendly procedure for the one-pot synthesis of highly substituted pyrazole derivatives has been developed via the reaction of various aldehydes, malononitrile and phenylhydrazine or 4-phenylthiosemicarbazide in PEG

CuCl3: As an efficient catalyst for the preparation of 5-amino-1H-pyrazole-4-carbonitriles by anomeric based oxidation

3-Methyl-1-sulfonic acid imidazolium trichlorido copper (II) {[Msim]CuCl3} was prepared and used as a new catalyst for the preparation of 5-amino-1H-pyrazole-4-carbonitriles. In this reaction, the pyrazole ring was formed by an anomeric and vinylogous ano

Glucose-coated superparamagnetic nanoparticle-catalysed pyrazole synthesis in water

A green, benign, heterogeneous, superparamagnetic catalyst (Glu.@Fe3O4) was synthesized and characterized using Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy and vibrating sample magnetometry. The prepared catalyst was used to achieve a high-efficiency, low-cost, eco-friendly and easy-to-handle protocol for synthesizing substituted pyrazole derivatives from aldehydes, malononitrile and phenylhydrazine. The catalyst was also used in chromene synthesis. Glucose coated on magnetic nanoparticles provided excellent catalytic activity. The catalyst could be recycled for up to four runs without significant loss in catalytic activity.

One-pot and efficient synthesis of 5-aminopyrazole-4-carbonitriles catalyzed by potassium phthalimide

The potassium phthalimide (PPI) has been found to be an efficient, recyclable, inexpensive, commercially available, and easy to handle catalyst for the synthesis of 5-aminopyrazole-4-carbonitriles through the one-pot, three-component reaction of easily av

Atmospheric oxygen mediated synthesis of pyrazole under visible irradiation

A novel protocol has been reported for synthesis of pyrazoles by visible light irradiation in the presence of eosin Y, an organophotocatalyst under atmospheric oxygen. We have successfully carried out a visible light induced Michael addition followed by i

Efficient iodine-catalyzed one pot synthesis of highly functionalised pyrazoles in water

An efficient one pot multi-component sequential reaction of phenyl hydrazine, malanonitrile and a diverse range of aldehydes to afford highly functionalised pyrazoles is reported. The reaction proceeds in water using molecular iodine as a catalyst, with no by-product formation, and involves simple operation requiring no column chromatography. Thus, this protocol fulfils all of the criteria that define green chemistry. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2014.