5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile
• CAS No.: 1017689-97-2
• Molecular Formula: C₁₆H₁₁FN₄
• Molecular Weight: 278.289
• Mol file: 1017689-97-2.mol

Synonyms:5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile

Chemical Property of 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile

There total 3 articles about 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-fluorobenzaldehyde (459-57-4) + phenylhydrazine (100-63-0) + malononitrile (109-77-3) → 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile (1017689-97-2)

Guidance literature:

In water; at 20 ℃; for 0.166667h; Sonication; Green chemistry;

DOI:10.1016/j.cclet.2015.07.009

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile (1017689-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-butyl-3-methylimidazolium hydroxide / water / Green chemistry

2: 1-butyl-3-methylimidazolium hydroxide / water / 10 h / Green chemistry

With 1-butyl-3-methylimidazolium hydroxide; In water; 1: |Knoevenagel Condensation / 2: |Michael Addition;

DOI:10.1039/c3ra42493f

Reference yield:

4-fluorobenzylidenemalononitrile (2826-22-4) + phenylhydrazine (100-63-0) → 5-amino-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile (1017689-97-2)

Guidance literature:

With 1-butyl-3-methylimidazolium hydroxide; In water; for 10h; Green chemistry;

DOI:10.1039/c3ra42493f

upstream raw materials:

4-fluorobenzaldehyde

phenylhydrazine

malononitrile

4-fluorobenzylidenemalononitrile