101858-69-9Relevant articles and documents
An iterative route to "decorated" ethylene glycol-based linkers
Lu, Genliang,Lam, Sang,Burgess, Kevin
, p. 1652 - 1654 (2006)
Iterative copper-catalyzed cycloadditions of azides to alkynes were used to join functionalized triethylene glycol molecules to give "linkers" of defined lengths equipped with several different end-group functionalities. The Royal Society of Chemistry 200
Cooperative and ion-pair recognition by heteroditopic calix[4]diquinone receptors
Lankshear, Michael D.,Dudley, Ian M.,Chan, Kar-Man,Cowley, Andrew R.,Santos, Sergio M.,Felix, Vitor,Beer, Paul D.
, p. 2248 - 2263 (2008)
A new family of heteroditopic calix[4]diquinone receptors capable of the cooperative recognition of ion-pair species through a contact binding mechanism has been developed. The receptors bind contact ion pairs cooperatively, with an unprecedented AND recognition phenomenon being observed to operate in certain cases, in which receptors display no affinity for either of the individual "free" cation or anion, but bind the cation and anion ion-pair strongly. X-ray crystallographic, solution-state, and computational methods rationalize the observed recognition behavior of the receptors. It is shown that the contact ion-pair interaction occurs through a π-stacking-mediated folding of the receptors such that the anion and cation binding sites are arranged in close proximity, while in the solid state an unusual ion-mediated receptor dimerization is observed. Molecular dynamics simulations are further used to explain the observed trends in the association constants of different ion-pair species and the mechanism of interaction.
MDM2 DEGRADERS AND USES THEREOF
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Paragraph 001343; 001346-001347, (2021/09/26)
The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog ("MDM2") protein via ubiquitination and/or degradation by compounds according to the present invention.
Tuning the strength and selectivity of ion-pair recognition using heteroditopic calix[4]arene-based receptors
Lankshear, Michael D.,Dudley, Ian M.,Chan, Kar-Man,Beer, Paul D.
, p. 684 - 690 (2008/02/12)
The syntheses, characterisation and ion binding properties of two novel heteroditopic calix[4]arene receptors are reported. These systems were found to demonstrate cooperative binding of certain ion-pairs, with the selectivity depending critically on the structure of the receptors. Furthermore, a macrocyclic effect for ion-pair recognition was observed to operate. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.