101860-97-3

Basic information

• Product Name: 2-(2-AMinopyridin-3-yl)acetic acid
• Synonyms: 2-(2-AMinopyridin-3-yl)acetic acid;2-Amino-3-pyridineacetic acid
• CAS NO: 101860-97-3
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15062
• Mol File: 101860-97-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 219-221.5℃ (decomposition)
• Boiling Point: 379.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.353±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.50±0.10(Predicted)
• CAS DataBase Reference: 2-(2-AMinopyridin-3-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-AMinopyridin-3-yl)acetic acid(101860-97-3)
• EPA Substance Registry System: 2-(2-AMinopyridin-3-yl)acetic acid(101860-97-3)

Safety Data

• Hazardous Substances Data: 101860-97-3(Hazardous Substances Data)

Usage

General Description

2-(2-Aminopyridin-3-yl)acetic acid is a chemical compound that includes functional groups like amino group, acetic acid and Pyridine ring. It is classified under Pyridines and its derivatives. The Amino group in its structure contributes to its basicity while the acetic acid group contributes to its acidity. It features properties of both classes. This chemical compound is generally used in the field of organic synthesis and can be utilised as an intermediate for the preparation of other complex molecules in the pharmaceutical and agrochemical industries. The specific properties such as solubility, melting and boiling point of this compound can vary greatly depending on the conditions such as pressure, purity of the compound and temperature.

Upstream product

• 101012-32-2 2-(2-chloropyridin-3-yl)acetonitrile 
• 1071087-00-7 3-(2-trimetylacetylamino)pyridylacetic acid 
• 86847-66-7 2,2-dimethyl-N-(3-methylpyridin-2-yl)propionamide 
• 6959-48-4 3-chloromethylpyridinium chloride 
• 6635-88-7 3-(cyanomethyl)pyridine 1-oxide 
• 6443-85-2 3-pyridinylacetonitrile 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 7758-99-8 copper(II) sulfate 

Downstream Products

• 5654-97-7 7-azaoxindole 

Relevant articles and documents

7,7′-Diazaindirubin - A small molecule inhibitor of casein kinase 2 in vitro and in cells

Aza- and diaza-bisindoles were synthesized by coupling of 7-azaisatin, 7-azaoxindol, 7-azaindoxyl acetate, and their non-aza counterparts, respectively. Whereas 7,7′-diazaindigo (10) and 7,7′-diazaisoindigo (11) did not show antiproliferative activity in several human tumor cell lines up to 100 μM, 7-azaindirubin (12) and 7′-azaindirubin (13) were more active than the parent molecule, indirubin, in LXFL529L cells (human large cell lung tumor xenograft), and 7,7′-diazaindirubin (14) was exhibiting substantially enhanced growth inhibitory activity in these cells. In the NCI 60 cell line panel, 14 displayed antiproliferative activity preferentially in certain melanoma and non-small cell lung cancer cells. In contrast to the potent serine/threonine/tyrosine kinase inhibition observed for indirubins, kinase inhibition profiling of 14 in 220 kinases revealed largely a loss of kinase inhibitory activity towards most kinases, with retained inhibitory activity for just a few kinases. At 1 μM concentration, especially casein kinases CK1γ3, CK2α, CK2α2, and SIK were inhibited by more than 50%. In cell-based assays, 14 markedly affected CK2-mediated signaling in various human tumor cells. In MCF7 cells, 14 induced cell cycle arrest at G1 and G2/M and apoptosis, whereas CK2-deficient MCF7 cells were resistant. These findings reveal a novel key mechanism of action for 14, suggesting primarily CK2 inhibition to be causally related to growth inhibition of human tumor cells.

Substituted 1-H-pyrrolopyridine-3-carboxamides

Substituted 1H-pyrrolopyridine-3-carboxamides and their use in pharmaceutical compositions and in treating inflammation are disclosed.